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Leuprolide
go.drugbank.com/drugs/DB00007ApprovedInvestigationalUnlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three … [A203222] As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels.
International brands: Prostap SR, Prostap 3Products: LUCRIN DEPOT 1 AY IM/SC 3,75 MG KULLANIMA HAZIR TOZ VE COZUCU ICEREN CIFT BOLMELI ENJEKTOR, TOZ ICEREN SIRINGA VE COZUCU ICEREN SIRINGA, 1 ADETEdrophonium
go.drugbank.com/drugs/DB01010ApprovedA rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.
Categories: Compounds used in a research, industrial, or household settingSynonyms: 3-hydroxy-N,N-dimethyl-N-ethylanilinium, N-ethyl-3-hydroxy-N,N-dimethylaniliniumInsulin aspart
go.drugbank.com/drugs/DB01306ApprovedInvestigationalInsulin is released from the pancreas following a meal to promote the uptake of glucose from the blood into internal organs and tissues such as the liver, fat cells, and skeletal muscle. … Insulin is an important treatment in the management of Type 1 Diabetes (T1D) which is caused by an autoimmune reaction that destroys the beta cells of the pancreas, resulting in the body not being able
Mixtures: Ryzodeg® FlexTouch® 100 U/ml Solution for Injection, RYZODEG PENFİLL 100 U/ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN KARTUŞ, 5 ADETCategories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 Enzyme InducersChloroquine
go.drugbank.com/drugs/DB00608ApprovedInvestigationalVet approvedChloroquine is an aminoquinolone derivative first developed in the 1940s for the treatment of malaria. … [A191655] It was the drug of choice to treat malaria until the development of newer antimalarials such as [pyrimethamine], [artemisinin], and [mefloquine].
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSynonyms: N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamineMetaraminol
go.drugbank.com/drugs/DB00610ApprovedIt has been used primarily as a vasoconstrictor in the treatment of hypotension. … An adrenergic agonist that acts predominantly at alpha adrenergic receptors and also stimulates the release of norepinephrine.
Synonyms: 1-(m-Hydroxyphenyl)-2-amino-1-propanol, 2-Amino-1-(m-hydroxyphenyl)-1-propanolCategories: Adrenergic alpha-1 Receptor AgonistsIndalpine
go.drugbank.com/drugs/DB08953ApprovedWithdrawnHowever, after the emergence of widespread concern regarding adverse effects caused by SSRIs, and reported hematological effects caused by Indalpine, it was abruptly withdrawn from the US market. … Indalpine was one of the first selective serotonin reuptake inhibitors to reach the American market. It was initially marketed by Pharmuka.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Cytochrome P-450 SubstratesOcrelizumab
go.drugbank.com/drugs/DB11988ApprovedInvestigational[A31739] Compared to non-humanized CD20 antibodies such as [rituximab], ocrelizumab is expected to be less immunogenic with repeated infusions, improving the benefit-to-risk profile for patients with MS … [A18875,A251745] MS is a chronic, inflammatory, autoimmune disease of the central nervous system that leads to neurological disabilities and a significantly reduced quality of life.
Products: OCREVUS® CONCENTRADO PARA SOLUCION PARA INFUSION 300MG/10ML, OCREVUS 300 MG/10 ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 2 ADETLumiracoxib
go.drugbank.com/drugs/DB01283ApprovedWithdrawnLumiracoxib is a COX-2 selective non-steroidal anti-inflammatory drug (NSAID). … On August 11, 2007, Australia's Therapeutic Goods Administration (TGA, the Australian equivalent of the FDA) cancelled the registration of lumiracoxib in Australia due to concerns that it may cause liver
Synonyms: 2-((2-chloro-6-fluorophenyl)amino)-5-methylbenzeneacetic acidCategories: COX-2 Inhibitors, Cytochrome P-450 SubstratesMisoprostol
go.drugbank.com/drugs/DB00929ApprovedInvestigationalMisoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions. … [L7616,L7619,A181589,A181583,A181697] The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the
Categories: Prostaglandins E, SyntheticProducts: CYTIL® V 200 MCG, CYTIL® FASTCoagulation factor VII human
go.drugbank.com/drugs/DB13150ApprovedInvestigationalCoagulation factor VII is human serine protease type enzyme that is involved in the extrinsic coagulation cascade which results in blood clotting.
Mixtures: Beriplex P/n 500, Beriplex P/n 1000Categories: coagulation factor IX, II, VII and X in combination