Coagulation factor VII human is a coagulation factor used to treat bleeding disorders such as hemophilia and Glanzmann's thrombasthenia. Coagulation factor VII is human serine protease type enzyme that is involved in the extrinsic coagulation cascade which results in blood clotting.
- Mechanism
- Curator reviewed
Factor VII is required in the extrinsic clotting cascade. When there is vascular damage tissue factor (TF) is released which then interacts with Factor VII resulting in the formation of the activated complex VIIa. Factor VIIa then continues to activate coagulation factors in the cascade until a clot is formed.
- Primary indication
- May be administered in cases of uncontrolled bleeding.Curator reviewed · 1 structured indication
- First approval
- Canada, 2007 · United States, 2013
- Also known as
- Coagulation factor VII (human) · Factor VII · Factor VII (proconvertin) · Factor VII human · Human coagulation factor VII
- Brand names
Resolves to
What you can answer from here — as of June 15, 2026
Which drugs share a target with Coagulation factor VII human, and which of those have an active Phase 3 trial?
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