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Zytron

DMPA has been investigated for the prevention, treatment, and basic science of Weight and Microbiota. … Zytron (DMPA) is under investigation for the treatment and health services research of HIV, Lactation, Contraception, Postpartum Depression, and Immune Cells (Mucosal and Systemic).

Unexpanded umbilical cord-derived allogeneic CD34- hematopoietic stem cells

in adult patients for whom a suitable donor is not available. … [L54116,L54106] Zemcelpro is the first approved cell therapy for blood cancer patients lacking suitable donor cells.[L54116]

Tiopronin

Patients with cystinuria excrete high levels of cystine in their urine and are at risk for kidney stone formation. … It is similar to d-penicillamine in use and efficacy, but offers the advantage of far less adverse effects.

Sapropterin

Sapropterin (tetrahydrobiopterin or BH4) is a cofactor in the synthesis of nitric oxide. It is also essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase; the conversion of tyrosine to L-dopa ...

Human botulinum neurotoxin A/B immune globulin

[L39819,L39824] BabyBIG (human-derived botulism immunoglobulin) was approved for use by the FDA in 2003[L39814] and has since been used to treat more than 2100 cases of infant botulism.

Neuropeptide Y

Neuropeptide Y is under investigation for the basic science of Type 2 Diabetes Mellitus.

Asenapine

It is also for severe post-traumatic stress disorder nightmares in soldiers as an off-label use. FDA approved on August 13, 2009. … Developed by Schering-Plough after its merger with Organon International, asenapine is a sublingually administered, atypical antipsychotic for treatment of schizophrenia and acute mania associated with

HY10275

This dual-acting receptor activity and the lack of affinity for undesired off- target receptors are thought to account for the compounds excellent efficacy and tolerability profile. … HY10275 is highly selective for histamine H1 and serotonin 5HT2a, two chemical receptors that are known to impact the ability to fall asleep and stay asleep.

Human papillomavirus type 16 L1 capsid protein residues 2-471 antigen

Oliceridine

[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid receptor subtype is predominantly targeted by and is responsible for the effects of … [A218026, A218031, A218036, A218041, A218046] Oliceridine (formerly known as TRV130) is a "biased agonist" at the μ-opioid receptor by preferentially activating the G-protein pathway with minimal receptor