Asenapine

DB06216ApprovedInvestigationalSmall moleculeAntipsychotic AgentsAntipsychotic Agents (Second Generation [Atypical])

Asenapine is an atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia. Asenapine also belongs to the dibenzo-oxepino pyrrole class.

Chemical structure of Asenapine
Mechanism
Curator reviewed
Primary indication
Used for treatment in psychosis, schizophrenia and schizoaffective disorders, manic disorders, and bipolar disorders as monotherapy or in combination.Curator reviewed · 6 structured indications
Formula / weight
C17H16ClNO · 285.77 g/mol (avg)
First approval
Canada, 2021 · United States, 2009 · European Union, 2016
Code names
ORG-5222
Brand names
  • Saphris
  • Secuado
  • Sycrest

Resolves to

Compound
UNIIJKZ19V908OCAS65576-45-6ChEMBLCHEMBL3187365ChEBI71255PubChem11954293KEGGD02995
Clinical / RWD
RxNorm784649ATCN05AH05
Structure
InChIKeyVSWBSWWIRNCQIJ-UHFFFAOYSA-NSMILESCN1CC2C(C1)C1=C(OC3=CC=C(Cl)C=C23)C=CC=C1
Targets
P28223HTR2AP14416DRD2P08908HTR1AP28222HTR1BP41595HTR2BP28335HTR2CP47898HTR5AP50406HTR6+12 more

What you can answer from here — as of August 30, 2026

20Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
1,745Drug interactionsStructured to mechanism, not free text
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27Clinical trialsPhase, status and sponsor resolved per trial
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6Structured indicationsCondition, population, route and combination as fields, not prose
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2ContraindicationsEach with its own population and attribute set
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57Marketed productsAcross 6 countries and 13 labellers
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1ATC codeIncluding every combination product, plus 44 drug categories
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55+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Asenapine, and which of those have an active Phase 3 trial?

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