Search
Bimekizumab
go.drugbank.com/drugs/DB12917ApprovedInvestigationalBimekizumab is a humanized monoclonal antibody directed towards IL-17, which was approved for use in the EU on August 20, 2021, for the treatment of plaque psoriasis. … [A244455] It has demonstrated superior efficacy as compared to another IL-17 inhibitor, [secukinumab], as well as [ustekinumab] (an IL-12/23 inhibitor) and [adalimumab] (a TNF inhibitor) in the treatment
Remlarsen
go.drugbank.com/drugs/DB19131InvestigationalRemlarsen is under investigation in clinical trial NCT03601052 (Efficacy, Safety, and Tolerability of Remlarsen (MRG-201) Following Intradermal Injection in Subjects With a History of Keloids).
Synonyms: -cholest-5-en-3-yloxy)hexyl)oxy)-2-hydroxypropyl hydrogen phosphate), complex with rna ((2'-deoxy-2'-fluoro)u-a-g-(2'-deoxy-2'-fluoro)c-a-(2'-deoxy-2'-fluoro)c-(2'-de, Rna, (am-am-cm-a-cm-um-g-um-um-um-a-cm-a-a-a-um-g-g-um-cm-cm-um-a), 3'-(3-((6-((3.beta.)Methyclothiazide Action Pathway
smpdb.ca/view/SMP0000081Drug actionMethyclothiazide (also known as Enduron or Methyclothiazid) is an organic compound that used for diuretic. It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water rea...
Enzymes: Y+L amino acid transporter 2, Y+L amino acid transporter 1Hydroflumethiazide Action Pathway
smpdb.ca/view/SMP0000108Drug actionHydroflumethiazide (also known as Saluron or Diuredemina) is an organic compound that used for diuretic. It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabs...
Enzymes: Y+L amino acid transporter 2, Y+L amino acid transporter 1Furosemide Action Pathway
smpdb.ca/view/SMP0000115Drug actionFurosemide (also named Lasix) is a medication that can be used for high blood pressure and fluid build-up which caused by heart failure, liver scarring, or kidney disease. Furosemide can bind and inhibit sodium-potassium-chloride cotrans...
Enzymes: Y+L amino acid transporter 2, Y+L amino acid transporter 1Trichlormethiazide Action Pathway
smpdb.ca/view/SMP0000121Drug actionTrichlormethiazide is a pharmacologically-active small molecule that belongs to a class of drugs called thiazides. Thiazides and thiazide-like drugs are diuretics commonly employed to control hypertension. Trichloromethiazide acts by inh...
Enzymes: Y+L amino acid transporter 2, Y+L amino acid transporter 1Eplerenone Action Pathway (Old)
smpdb.ca/view/SMP0000135Drug actionEplerenone is a potassium-sparing diuretic. It acts by competing with aldosterone for its receptor inside the principal cells of the late distal tubule and collecting tubule. Aldosterone increases sodium reabsorption and potassium excret...
Enzymes: Y+L amino acid transporter 2, Y+L amino acid transporter 1Kidney Function
smpdb.ca/view/SMP0000483PhysiologicalKidneys are regulatory organs involved in removing wastes from the blood, hormone production, nutrient reabsorption, and regulating electrolyte concentrations, acid-base balance, extracellular fluid volume, and blood pressure. The early ...
Enzymes: Y+L amino acid transporter 2, Y+L amino acid transporter 1Cystinuria
smpdb.ca/view/SMP0000723DiseaseCystinuria is a genetic condition caused by mutations in the SLC7A9 or SLC3A1 gene. These two genes are responsible for creating subunits of a protein that reabsorbs cystine into the blood, located in the kidneys. The mutations cause thi...
Enzymes: Y+L amino acid transporter 2, Y+L amino acid transporter 1Flurandrenolide
go.drugbank.com/drugs/DB00846Approved(From Martindale, The Extra Pharmacopoeia, 30th ed, p733) … A corticosteroid used topically in the treatment of various skin disorders. It is usually employed as a cream or an ointment, and is also used as a polyethylene tape with an adhesive.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: Drenison Tape M 170 4mcg Sq Cm