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Potassium bitartrate
go.drugbank.com/drugs/DB11107ApprovedInvestigationalPotassium bitartrate was one of active ingredients in Phexxi, a non-hormonal contraceptive agent that was approved by the FDA on May 2020.[L14120]
Afamelanotide
go.drugbank.com/drugs/DB04931Approved[L9092] Despite its relatively recent approval, afamelanotide has been available for use as an orphan drug in both the US and EU since 2008.[L9122,L9125]
Synonyms: MT-ITeprotumumab
go.drugbank.com/drugs/DB06343ApprovedInvestigationalin which its efficacy in the treatment of thyroid eye disease (TED) was assessed, it received "breakthrough therapy" designation from the FDA in 2016[A190129] and was approved by the FDA in January 2020
Pegylated Recombinant Human Arginase I
go.drugbank.com/drugs/DB16282InvestigationalPegylated Recombinant Human Arginase I is under investigation in clinical trial NCT03455140 (A Study Evaluating the Safety and Activity of Pegylated Recombinant Human Arginase (BCT-100)).
Synonyms: Pegylated recombinant human arginase i bct-100Vafidemstat
go.drugbank.com/drugs/DB16446InvestigationalVafidemstat is under investigation in clinical trial NCT03867253 (Testing the Safety and Preliminary Efficacy of the New Drug ORY-2001 in Mild to Moderate Alzheimer's Disease).
Herpes simplex of the oral-labial
go.drugbank.com/conditions/DBCOND0024319Drugs: AcyclovirSynonyms: Herpes simplex complexME-344
go.drugbank.com/drugs/DB13062InvestigationalME-344 has been used in trials studying the treatment of Solid Tumors.
Trofinetide
go.drugbank.com/drugs/DB06045Approved[A258438] Trofinetide was approved by the FDA on March 10, 2023, for the treatment of Rett syndrome,[L45718,L45748] which is an X-linked neurodevelopmental disorder characterized by a range of cognitive
Rezafungin
go.drugbank.com/drugs/DB16310ApprovedInvestigational[A258403] In March 2023, the FDA approved rezafungin for injection for the treatment of candidemia and invasive candidiasis in adults with limited or no alternative treatment options.
Danicopan
go.drugbank.com/drugs/DB15401ApprovedInvestigational[A263506] It was subsequently approved by the FDA in March 2024.[L50386]