Rezafungin

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Rezafungin
DrugBank Accession Number
DB16310
Background

Rezafungin is under investigation in clinical trial NCT04368559 (Study of Rezafungin Compared to Standard Antimicrobial Regimen for Prevention of Invasive Fungal Diseases in Adults Undergoing Allogeneic Blood and Marrow Transplantation).

Type
Small Molecule
Groups
Investigational
Structure
Thumb
Weight
Average: 1226.411
Monoisotopic: 1225.602719729
Chemical Formula
C63H85N8O17
Synonyms
  • Biafungin
  • Rezafungin
  • Rezafungin cation
  • Rezafungin ion
External IDs
  • CD-101
  • CD101
  • SP-3025

Pharmacology

Indication

Not Available

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Medicalerrors
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
G013B5478J
CAS number
1396640-59-7
InChI Key
LNFCWEXGZIEGJW-AMIBTTDLSA-O
InChI
InChI=1S/C63H84N8O17/c1-8-9-10-28-87-45-25-21-40(22-26-45)38-13-11-37(12-14-38)39-15-17-42(18-16-39)56(80)64-46-31-48(76)61(88-29-27-71(5,6)7)68-60(84)52-53(77)34(2)32-70(52)63(86)50(36(4)73)66-59(83)51(55(79)54(78)41-19-23-43(74)24-20-41)67-58(82)47-30-44(75)33-69(47)62(85)49(35(3)72)65-57(46)81/h11-26,34-36,44,46-55,61,72-73,75-79H,8-10,27-33H2,1-7H3,(H5-,64,65,66,67,68,74,80,81,82,83,84)/p+1/t34-,35+,36+,44+,46-,47-,48+,49-,50-,51?,52-,53-,54-,55-,61+/m0/s1
IUPAC Name
(2-{[(3S,9S,11R,15S,18S,20R,21R,24S,25S,26S)-6-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,25-trihydroxy-3,15-bis[(1R)-1-hydroxyethyl]-26-methyl-2,5,8,14,17,23-hexaoxo-18-{4-[4'-(pentyloxy)-[1,1'-biphenyl]-4-yl]benzamido}-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0^{9,13}]heptacosan-21-yl]oxy}ethyl)trimethylazanium
SMILES
[H][C@@]12C[C@@H](O)CN1C(=O)[C@@]([H])(NC(=O)[C@H](C[C@@H](O)[C@H](NC(=O)[C@]1([H])[C@@H](O)[C@@H](C)CN1C(=O)[C@@]([H])(NC(=O)C(NC2=O)[C@H](O)[C@@H](O)C1=CC=C(O)C=C1)[C@@H](C)O)OCC[N+](C)(C)C)NC(=O)C1=CC=C(C=C1)C1=CC=C(C=C1)C1=CC=C(OCCCCC)C=C1)[C@@H](C)O

References

General References
Not Available
ChemSpider
52083167

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3RecruitingPreventionAspergillus / Candidemia / Candidiasis, Invasive / Fungaemia / Infections, Fungal / Invasive Fungal Disease / Mold Infection / Mycoses / Pneumocystis / Prophylaxis Of Invasive Fungal Infections1
3RecruitingTreatmentCandidemia / Infections, Fungal / Invasive Candidiases / Mycoses1
2CompletedTreatmentCandidemia / Candidiasis, Invasive / Fungaemia / Infections, Fungal / Mycoses1
2CompletedTreatmentMoniliasis, Vulvovaginal / Mycoses / Vaginitis, Monilial / Vulvovaginal Candidiasis / Yeast Infections1
1CompletedTreatmentHealthy Volunteers2
1TerminatedPreventionInfections, Fungal1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.023 mg/mLALOGPS
logP0.29ALOGPS
logP-5ChemAxon
logS-4.7ALOGPS
pKa (Strongest Acidic)9.46ChemAxon
pKa (Strongest Basic)-3.3ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count17ChemAxon
Hydrogen Donor Count13ChemAxon
Polar Surface Area366.42 Å2ChemAxon
Rotatable Bond Count18ChemAxon
Refractivity330.98 m3·mol-1ChemAxon
Polarizability130.91 Å3ChemAxon
Number of Rings7ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on December 15, 2020 20:02 / Updated on February 21, 2021 18:55