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Displaying results 2731 - 2740 of 3599 in total
  1. Drug

    Futibatinib

    go.drugbank.com/drugs/DB15149
    ApprovedInvestigational

    Futibatinib is an inhibitor of Fibroblast Growth Factor receptor (FGFR), which comprises a group of receptor tyrosine kinases that play a key role in cell proliferation, differentiation, migration, and

    Categories: Fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors, P-glycoprotein inhibitors
  2. Drug

    Elexacaftor

    go.drugbank.com/drugs/DB15444
    ApprovedInvestigational

    Elexacaftor (previously VX-445) is a small molecule, next-generation corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. It received FDA approval in October 2019 in combination with tezacaftor and ivacaft...

    Categories: P-glycoprotein inhibitors, P-glycoprotein substrates
  3. Drug

    Zuranolone

    go.drugbank.com/drugs/DB15490
    ApprovedInvestigational

    positive allosteric modulators on the market like benzodiazepines, zuranolone can modulate both synaptic and extrasynaptic GABA<sub>A</sub> conductance due to binding to a non-benzodiazepine site on the receptor

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  4. Drug

    Pradefovir

    go.drugbank.com/drugs/DB15550
    Investigational

    Pradefovir is a prodrug of adefovir.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  5. Drug

    Desfesoterodine

    go.drugbank.com/drugs/DB15578
    Investigational

    Desfesoterodine is a metabolite of tolterodine.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 Substrates
  6. Drug

    Cryptotanshinone

    go.drugbank.com/drugs/DB15579
    Experimental

    Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP2C9 Inhibitors
  7. Drug

    JPC-3210

    go.drugbank.com/drugs/DB15609
    Experimental

    JPC-3210 is a potent antimalarial agent. It is an erythrocytic schizonticide with potent in vitro antimalarial activity against multidrug-resistant Plasmodium falciparum lines, low cytotoxicity, potent in vivo efficacy against murine mal...

    Categories: Cytochrome P-450 CYP2D6 Inhibitors, Cytochrome P-450 CYP3A Inhibitors
  8. Drug

    Pralsetinib

    go.drugbank.com/drugs/DB15822
    ApprovedInvestigational

    Pralsetinib, similar to the previously approved selpercatinib, is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes. Enhanced RET (Rearranged during transfection) oncogene expres...

    Categories: P-glycoprotein inhibitors, P-glycoprotein substrates
  9. Drug

    Lecithin

    go.drugbank.com/drugs/DB15834
    Investigational

    A complex mixture of phospholipids, glycolipids, triglycerides, phosphatidylcholines, phosphatidylethanolamines, and phosphatidylinositols.

    Categories: P-glycoprotein substrates
  10. Drug

    Methacetin methoxy-C-13

    go.drugbank.com/drugs/DB15885
    Investigational

    Synonyms: p-Acetanisidine C-13Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates