Zuranolone

DB15490ApprovedInvestigationalSmall moleculeNeuroactive Steroid Gamma-Aminobutyric Acid A Receptor Positive Modulator

Zuranolone is a neuroactive steroid drug used to treat postpartum depression. Zuranolone is a neuroactive steroid that acts as a positive allosteric modulator of the GABAA receptors.

Mechanism: The mechanism of action of zuranolone in the treatment of PPD is not fully understood but is thought to be related to its positive allosteric modulation of GABAA receptors.
Unlike benzodiazepines, another class of GABAA positive modulators, zuranolone binds to the α/β subunit interface presented in all GABAA receptors instead of the α/γ subunit interface. Therefore, zuranolone can bind to both synaptic GABAA receptors, composed of 2α2βγ subunits, and extrasynaptic GABAA receptors, composed of 2α2βδ subunits.
Curator reviewed · 3 references
Primary indication: Zuranolone is indicated for the treatment of postpartum depression (PPD) in adults.Curator reviewed · 1 structured indication
Formula / weight: C₂₅H₃₅N₃O₂ · 409.574 g/mol (avg)
First approval: Canada, 2025 · United States, 2023 · European Union, 2025
Code names: SAGE-217
Brand names: Zurzuvae

Resolves to

Compound

UNII7ZW49N180BCAS1632051-40-1ChEMBLCHEMBL4105630

Clinical / RWD

RxNorm2669905ATCN06AX31

Structure

InChIKeyHARRKNSQXBRBGZ-GVKWWOCJSA-NSMILES[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@](C)(O)CC[C@]4([H])[C@@]3([H])CC[C@]12C)C(=O)CN1C=C(C=N1)C#N

Targets

Q99928GABRG3

What you can answer from here — as of March 06, 2025

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

885Drug interactionsStructured to mechanism, not free text

14Clinical trialsPhase, status and sponsor resolved per trial

1Structured indicationCondition, population, route and combination as fields, not prose

13Marketed productsAcross 3 countries and 2 labellers

1ATC codeIncluding every combination product, plus 14 drug categories

9+ReferencesStructured and connected to the statements they support

Which drugs share a target with Zuranolone, and which of those have an active Phase 3 trial?

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