This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Pradefovir
- DrugBank Accession Number
- DB15550
- Background
Pradefovir is a prodrug of adefovir.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Pradefovir (DB15550)
- Weight
- Average: 423.79
Monoisotopic: 423.0863188 - Chemical Formula
- C17H19ClN5O4P
- Synonyms
- Pradefovir
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- GZE85Q9Q61
- CAS number
- 625095-60-5
- InChI Key
- GWNHAOBXDGOXRR-HJFSHJIFSA-N
- InChI
- InChI=1S/C17H19ClN5O4P/c18-13-3-1-2-12(8-13)14-4-6-26-28(24,27-14)11-25-7-5-23-10-22-15-16(19)20-9-21-17(15)23/h1-3,8-10,14H,4-7,11H2,(H2,19,20,21)/t14-,28+/m0/s1
- IUPAC Name
- (2R,4S)-2-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-4-(3-chlorophenyl)-1,3,2lambda5-dioxaphosphinan-2-one
- SMILES
- NC1=NC=NC2=C1N=CN2CCOC[P@@]1(=O)OCC[C@H](O1)C1=CC=CC(Cl)=C1
References
- General References
- Not Available
- External Links
- ChemSpider
- 7878773
- ChEMBL
- CHEMBL2096895
- ZINC
- ZINC000003939598
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Completed Treatment Hepatitis B Chronic Infection 1 2 Terminated Treatment Hepatitis B Chronic Infection 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.45 mg/mL ALOGPS logP 1.7 ALOGPS logP 1.81 Chemaxon logS -3 ALOGPS pKa (Strongest Acidic) 18.55 Chemaxon pKa (Strongest Basic) 3.75 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 114.38 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 104.06 m3·mol-1 Chemaxon Polarizability 39.12 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at October 13, 2019 16:25 / Updated at February 21, 2021 18:55