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Displaying results 2761 - 2770 of 10000 in total
  1. Drug

    Phylloquinone

    go.drugbank.com/drugs/DB01022
    ApprovedInvestigational

    Vitamin K1, also called phylloquinone or phytonadione, is a fat soluble vitamin. … [L33319,L33345] Phylloquinone is a cofactor of the enzyme γ-carboxylase, which modifies and activates precursors to coagulation factors II, VII, IX, and X.

  2. Drug

    Gefapixant

    go.drugbank.com/drugs/DB15097
    Approved

    It has been estimated that 5-10% of adults globally suffer from chronic cough, which is defined as a cough lasting longer than eight weeks. … [L48596,L48591] It is the first therapy to be approved for the treatment of RCC or UCC in the EU.[L48601]

  3. Drug

    Ixazomib

    go.drugbank.com/drugs/DB09570
    ApprovedInvestigational

    [A7948] More than 99% of the drug compound is the R-enantiomer.[A264329] Ixazomib was approved by the FDA on November 20, 2015, making it the first oral proteasome inhibitor approved in the US. … Ixazomib is a reversible proteasome inhibitor. Because it is a modified peptide boronic acid with one chiral center,[A264329] it is considered a boronate proteasome inhibitor.

  4. Drug

    CD68-ET3-LV

    go.drugbank.com/drugs/DB32864
    Investigational

    CD68-ET3-LV is an autologous gene therapy consisting of CD34+ hematopoietic stem and progenitor cells transduced ex-vivo with the CD68-ET3-LV lentiviral vector.

  5. Drug

    Tipiracil

    go.drugbank.com/drugs/DB09343
    ApprovedInvestigational

    Tipiracil is a thymidine phosphorylase inhibitor. It is used in combination with trifluridine, in a ratio of 1:0.5, to form TAS-102. … The main function of Tipiracil in TAS-102 is to increase trifluridine bioavailability by inhibiting its catabolism.

  6. Drug

    Trypsin

    go.drugbank.com/drugs/DB11237
    ApprovedInvestigationalVet approved

    Trypsin contains a nucleophilic residue Ser in the enzyme active site which attacks the carbonyl moiety of the substrate peptide bond to form an acyl-enzyme intermediate [A27241]. … Therapeutic forms of trypsin is obtained from purified extracts of porcine or bovine pancreas and is intended to aid in digestion when administered orally.

    Mixtures: Trypsin Complex
  7. Drug

    Galamustine

    go.drugbank.com/drugs/DB21062
    Experimental

    Galamustine is a small molecule drug. The usage of the INN stem '-mustine' in the name indicates that Galamustine is a antineoplastic, alkylating agent, (β-chloroethyl) amine derivative.

  8. Drug

    Barucainide

    go.drugbank.com/drugs/DB19585
    Experimental

    Barucainide is a small molecule drug. The usage of the INN stem '-cain-' in the name indicates that Barucainide is a class I antiarrhythmic, procainamide and lidocaine derivative.

  9. Drug

    Eptazocine

    go.drugbank.com/drugs/DB19670
    Experimental

    Eptazocine is a small molecule drug. The usage of the INN stem '-azocine' in the name indicates that Eptazocine is a narcotic antagonist/agonist related to 6,7-benzomorphan.

  10. Drug

    Suricainide

    go.drugbank.com/drugs/DB19705
    Experimental

    Suricainide is a small molecule drug. The usage of the INN stem '-cain-' in the name indicates that Suricainide is a class I antiarrhythmic, procainamide and lidocaine derivative.