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Disulfiram
go.drugbank.com/drugs/DB00822ApprovedInvestigationalA carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesCinoxacin
go.drugbank.com/drugs/DB00827ApprovedWithdrawnSynthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections.
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 Enzyme InhibitorsDiazepam
go.drugbank.com/drugs/DB00829ApprovedIllicitInvestigationalVet approvedA benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of gamma-aminobutyric acid activity. It is used in the treatment o...
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesTrifluoperazine
go.drugbank.com/drugs/DB00831ApprovedA phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesMifepristone
go.drugbank.com/drugs/DB00834ApprovedInvestigationalAs a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary cushing syndrome.
Categories: Progesterone Receptor Modulators, Progestational Hormone Receptor AntagonistsPrednisolone
go.drugbank.com/drugs/DB00860ApprovedInvestigationalVet approvedPrednisolone is a glucocorticoid similar to cortisol used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: P-PREDFlupentixol
go.drugbank.com/drugs/DB00875ApprovedInvestigationalWithdrawnFlupentixol is an antipsychotic drug of the thioxanthene group. It exists in two geometric isomers, the trans(E) and pharmacologically active cis(Z) forms. Flupentixol decanoate is one of the active ingredients found in injectable drug f...
Categories: P-glycoprotein inhibitors, Adrenergic alpha-1 Receptor AntagonistsEprosartan
go.drugbank.com/drugs/DB00876ApprovedInvestigationalEprosartan is an angiotensin II receptor antagonist used to treat hypertension. It performs 2 actions on the renin angiotensin system.
Categories: Angiotensin 2 Receptor Blocker, Angiotensin Receptor AntagonistsSynonyms: (E)-2-butyl-1-(p-carboxybenzyl)-α-2-thenylimidazole-5-acrylic acidClomifene
go.drugbank.com/drugs/DB00882ApprovedInvestigationalA triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.
Synonyms: 2-(p-(β-chloro-α-phenylstyryl)phenoxy)triethylamine, 2-(p-(2-chloro-1,2-diphenylvinyl)phenoxy)triethylamineCategories: P-glycoprotein substrates, Estrogen Receptor ModulatorsSulfapyridine
go.drugbank.com/drugs/DB00891ApprovedWithdrawnAntibacterial, potentially toxic, and previously used to treat certain skin diseases. No longer prescribed.
Synonyms: 2-(p-Aminobenzenesulphonamido)pyridineCategories: Cytochrome P-450 CYP2C9 Inhibitors, Cytochrome P-450 Enzyme Inhibitors