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Icotrokinra
go.drugbank.com/drugs/DB21724ApprovedInvestigationalIcotrokinra is a first-in-class, targeted oral peptide and interleukin-23 (IL-23) receptor antagonist. … It was jointly discovered and developed by Protagonist and Johnson & Johnson[L56118] and provides a novel, oral treatment option for patients requiring systemic therapy for plaque psoriasis.
Fomivirsen
go.drugbank.com/drugs/DB06759ApprovedWithdrawnAs a complementary nucleotide to the messenger RNA of the major immediate-early region proteins of human cytomegalovirus, it disrupts the replication of the virus through an antisense mechanism [L1428] … Fomivirsen is a antisense 21 mer phosphorothioate oligonucleotide.
Categories: Compounds used in a research, industrial, or household settingGadobenic acid
go.drugbank.com/drugs/DB00743ApprovedInvestigational[A263166] As gadobenate dimeglumine is specifically taken up by hepatocytes and excreted through the biliary system, it is a useful contrast agent for liver MRI. … [A263086] It differs from other GBCAs due to the benzene ring that confers weak protein binding, thus leading to an increased R1 and R2 relaxivity.
Categories: Compounds used in a research, industrial, or household settingBromopride
go.drugbank.com/drugs/DB09018InvestigationalBromopride is a dopamine antagonist used as an antiemetic. Its prokinetic properties are similar to those of metoclopramide. It is unavailable in America or the United Kingdom.
Categories: Dopamine D2 Receptor AntagonistsPrucalopride
go.drugbank.com/drugs/DB06480ApprovedInvestigationalPrucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. … [A37348] The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies.
Categories: Serotonin Receptor Agonists, Serotonin-4 Receptor AgonistAlfimeprase
go.drugbank.com/drugs/DB04919InvestigationalIt is a small protein that contains 203 residues (Randolph et al. 1992). Alfimeprase is being developed by Nuvelo. … Alfimeprase is a recombinant analog of fibrolase. Fibrolase is a zinc-containing metalloproteinase isolated from the venom of the southern copperhead snake (<i>Agkistrodon contortrix contortrix</i>).
Ubenimex
go.drugbank.com/drugs/DB03424InvestigationalUbenimex (also known as bestatin) is a competitive protease inhibitor. It is an inhibitor of aminopeptidase B, leukotriene A4 hydrolase, aminopeptidase N.
Exagamglogene autotemcel
go.drugbank.com/drugs/DB15572ApprovedInvestigationalmainstay of treatment since the 1990s - as well as newer agents like [crizanlizumab] and [voxelotor]. … [L10139] Following engraftment, it causes an increase in the production of HbF and a subsequent decrease in HbS.
Synonyms: from mobilised peripheral blood by positive selection, modified by CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9) mediated gene editing consisting of aToripalimab
go.drugbank.com/drugs/DB15043ApprovedInvestigational[L48681] Toripalimab is a selective, recombinant, humanized IgG4 monoclonal antibody targeted against the PD-1 receptor. … The proliferation of some cancers can be attributed, at least in part, to the suppression of host tumor surveillance.
Categories: Programmed Death Receptor-1 Blocking AntibodyDetomidine
go.drugbank.com/drugs/DB11556InvestigationalVet approvedDetomidine is an α2-adrenergic agonist that is used as a horse sedative. Normally, it is administered in the salt form, detomidine hydrochloride. … This drug is prescribed by veterinarians and is marketed as _Dormosedan_. Currently, it is only approved by the FDA for use in horses but has been studied for use in other large animals.
Categories: Adrenergic alpha-2 Receptor Agonists