This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Toripalimab
- DrugBank Accession Number
- DB15043
- Background
Toripalimab is under investigation in clinical trial NCT03919383 (Phase II of Lenvatinib Plus Toripalimab for Advanced HCC).
- Type
- Biotech
- Groups
- Investigational
- Synonyms
- Toripalimab
- External IDs
- JS 001
- JS-001
- JS001
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism UProgrammed cell death protein 1 inhibitorantibodyHumans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 8JXN261VVA
- CAS number
- 1924598-82-2
References
- General References
- Not Available
- External Links
- Not Available
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Not Yet Recruiting Treatment Breast Cancer 1 3 Active Not Recruiting Treatment Advanced Hepatocellular Carcinoma (HCC) 1 3 Active Not Recruiting Treatment Advanced or Metastatic Esophageal Squamous Cell Cancer Without Previous Systemic Chemotherapy 1 3 Active Not Recruiting Treatment Recurrent or Metastatic NPC 1 3 Active Not Recruiting Treatment Triple-Negative Breast Cancer 1 3 Completed Treatment Treatment-naive Advanced Non-small Cell Lung Cancer 1 3 Enrolling by Invitation Treatment Hepatocellular Carcinoma 1 3 Not Yet Recruiting Treatment Intrahepatic Cholangiocarcinoma 1 3 Not Yet Recruiting Treatment Locally Advanced or Metastatic Urothelial Carcinoma (UC) 1 3 Not Yet Recruiting Treatment NSCLC (Non-Small Cell Lung Cancer) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
Targets
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- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- InhibitorAntibody
- General Function
- Signal transducer activity
- Specific Function
- Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. ...
- Gene Name
- PDCD1
- Uniprot ID
- Q15116
- Uniprot Name
- Programmed cell death protein 1
- Molecular Weight
- 31646.635 Da
Drug created at May 20, 2019 14:44 / Updated at February 21, 2021 18:55