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Samidorphan
go.drugbank.com/drugs/DB12543ApprovedInvestigational, and a longer half-life, making it an attractive candidate for oral dosing. … [A235638, A235643] Samidorphan is a novel opioid antagonist structurally related to [naltrexone], with a higher affinity for opioid receptors, more potent μ-opioid receptor antagonism, higher oral bioavailability
Categories: Heterocyclic Compounds with 4 or More RingsFexapotide
go.drugbank.com/drugs/DB05493InvestigationalNX-1207 is an investigational new drug for BPH, whose chemical entity and mechanism of action remain undisclosed. … Nymox Pharmaceutical Corporation recently completed studies of NX-1207 for treatment of benign prostatic hyperplasia (BPH).
Berberine
go.drugbank.com/drugs/DB04115ApprovedInvestigationalWithdrawnIt is relatively toxic parenterally, but has been used orally for various parasitic and fungal infections and as antidiarrheal.
Categories: Heterocyclic Compounds with 4 or More RingsChlorfenson
go.drugbank.com/drugs/DB05377ExperimentalChlorfenson is developed by Moberg Derma for the treatment of onychomycosis (nail fungus) as the primary indication.
Lysergic acid diethylamide
go.drugbank.com/drugs/DB04829IllicitInvestigationalExplanations in terms of LSD physically remaining in the body for months or years after consumption have been discounted by experimental evidence. … However, not all published case reports of chronic flashbacks appear to describe an anxious hyper-vigilant state reminiscent of post-traumatic stress disorder.
Categories: Heterocyclic Compounds with 4 or More RingsLuteinizing hormone
go.drugbank.com/drugs/DB14741ApprovedInvestigationalMixtures: MENOGON 75 IU Powder and Solvent for solution for InjectionHuman papillomavirus type 16 L1 capsid protein residues 2-471 antigen
go.drugbank.com/drugs/DB10994ApprovedWithdrawnMixtures: CERVARIX SUSPENSION FOR INJECTIONMetipranolol
go.drugbank.com/drugs/DB01214ApprovedWithdrawnA beta-adrenergic antagonist effective for both beta-1 and beta-2 receptors. It is used as an antiarrhythmic, antihypertensive, and antiglaucoma agent.
Tafenoquine
go.drugbank.com/drugs/DB06608ApprovedInvestigational[A35690] Tafenoquine was further developed collaboratively between GlaxoSmithKline and Medicines for Malaria Venture.[A35677] It was FDA approved on July 20, 2018.[L3770] … [A35671, A35690] It was discovered by the scientists at the Walter Reed Army Institute of Research in 1978 as a substitute for primaquine that would be more effective against relapsing vivax malaria.
INM005
go.drugbank.com/drugs/DB16499InvestigationalINM005 was under investigation in clinical trials for the treatment of COVID-19. It was studied for pharmacokinetics, efficacy, and safety in a completed trial (NCT04494984). … Additionally, a retrospective cohort study investigated the effectiveness and safety of specific hyperimmune equine serum for severe hospitalized COVID-19 patients (NCT04954235)
Categories: Experimental Unapproved Treatments for COVID-19