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Flibanserin
go.drugbank.com/drugs/DB04908ApprovedInvestigationalFlibanserin's mechanism of action is attributed to its high affinity for 5-HTA1 and 5-HTA2 receptors, displaying agonist activity on 5-HTA1 and antagonist on 5-HTA2, resulting in lowering of serotonin … Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Serotonin 5-HT1 Receptor AgonistsBelumosudil
go.drugbank.com/drugs/DB16703ApprovedInvestigational[A236634] It is an inhibitor of rho-associated coiled-coil-containing protein kinases (ROCK), with significantly more selectivity for ROCK2 as compared to ROCK1 (IC<sub>50</sub> 100 nM vs. 3 μM, respectively … [L34754] In July 2022, Belumosudil was approved by Health Canada under the brand name RHOLISTIQ to treat the same condition in adult and pediatric patients 12 years or older.[L42925]
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsEntamoebic histolytica infection
go.drugbank.com/conditions/DBCOND0024177Drugs: TetracyclineSynonyms: Disease due to Endamoebidae (disorder)Dextropropoxyphene
go.drugbank.com/drugs/DB00647ApprovedIllicitWithdrawnDue to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the market in Europe and the United States. … The levo-isomer appears to exhibit a very limited antitussive effect.
Mixtures: Darvocet-N 100, Darvocet-N 50Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Cytochrome P-450 SubstratesZinc acetate
go.drugbank.com/drugs/DB14487ApprovedInvestigationalMixtures: Johnson and Johnson First Aid All Purpose 160 CT, Benadryl Bug Bite ReliefRivanicline
go.drugbank.com/drugs/DB05855ExperimentalIt was originally developed as a potential treatment for Alzheimer's disease for its nootropic effects but has also been found to inhibit the production of Interleukin-8. … Rivanicline (TC-2403, RJR-2403, (E)-metanicotine) is a partial agonist at neuronal nicotinic acetylcholine receptors, binding primarily to the α4β2 subtype.
Synonyms: (3E)-N-methyl-4-(pyridin-3-yl)but-3-en-1-amineTranscription elongation factor SPT5
go.drugbank.com/bio_entities/BE0011188TargetHumansDSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782 … TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896).
Synonyms: DRB sensitivity-inducing factor 160 kDa subunitN-acetyltyrosine
go.drugbank.com/drugs/DB11102ApprovedInvestigationalN-acetyltyrosine is administered as parenteral nutrition or intravenous infusion due to its enhanced solubility compared to tyrosine [A32652]. … N-acetyltyrosine, also referred to as N-acetyl-L-tyrosine, is used in place of as a tyrosine precursor. [DB00135] is a non-essential amino acid with a polar side group.
Mixtures: Aminosyn II 7% M In 10% Dextrose(dual Chamber), AMINOVEN INFANT 10%Norelgestromin
go.drugbank.com/drugs/DB06713ApprovedInvestigational[L63816] Combined hormonal contraceptives containing norelgestromin lower the risk of pregnancy primarily by suppressing ovulation.
Mixtures: EVRA TRANSDERMAL PATCH (6 mg/600 mcg), Gwyn LoCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSulconazole
go.drugbank.com/drugs/DB06820Approved[L44592,L44597] Sulconazole appears to be effective and well-tolerated in the treatment of superficial fungal infections.[A255612]
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP2C9 Inhibitors