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Difelikefalin
go.drugbank.com/drugs/DB11938ApprovedInvestigationalDifelikefalin (CR845) is an agonist of kappa opioid receptors (KORs) useful in the treatment of pruritus secondary to chronic kidney disease. KORs were first associated with itching in 1984. … [A237610] These revelations led to the study of KOR agonists as a potential treatment option in patients suffering from pruritic conditions.
Categories: Heterocyclic Compounds, 1-RingGepirone
go.drugbank.com/drugs/DB12184ApprovedIt was not until an extended-release formulation of gepirone was made available that gepirone became a potential candidate for a new antidepressant. … Gepirone, an azapirone, is a pharmacologic analog of [buspirone] that acts selectively on the pre- and post-synaptic 5HT<sub>1A</sub> receptors.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingAmber
go.drugbank.com/drugs/DB14326InvestigationalAmber is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Mixtures: Ma Ying Long HemorrhoidalCategories: Compounds used in a research, industrial, or household settingNorclozapine
go.drugbank.com/drugs/DB05766InvestigationalIt combines an atypical antipsychotic efficacy profile with the added potential benefit of enhanced cognition, thereby addressing one of the major challenges in treating schizophrenia today. … ACP-104, or N-desmethylclozapine, is the major metabolite of clozapine, and is being developed by ACADIA as a novel, stand-alone therapy for schizophrenia.
Synonyms: N-DesmethylclozapineCategories: Heterocyclic Compounds, 3-RingZafirlukast
go.drugbank.com/drugs/DB00549ApprovedZafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. … It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), which is usually taken just once daily.
Synonyms: 4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol-3-ylmethyl)-3-methoxy-N-o-tolylsulfonylbenzamide, cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carbamoyl)benzyl)-1-methylindole-5-carbamateCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsVP025
go.drugbank.com/drugs/DB05133ExperimentalVP025, a novel drug formulation based on phospholipid microparticles incorporating phosphatidylglycerol, can inhibit neuroinflammation. … VP025 may inhibit immune system activation and protect motoneurons from injury.
Bucetin
go.drugbank.com/drugs/DB13278ApprovedWithdrawnBucetin is an analgesic and antipyretic medication which was approved for use in Germany but was withdrawn from the market in 1986 due to renal toxicity caused by the medication.[A175636]
Mumps virus strain B level jeryl lynn live antigen
go.drugbank.com/drugs/DB10316ApprovedInvestigationalMumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease.
Mixtures: M-M-R II, M-M-R IISynonyms: Mumps virus strain B level jeryl lynn live antigenQuinacrine
go.drugbank.com/drugs/DB01103InvestigationalAn acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. … It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: 3-chloro-7-methoxy-9-(1-methyl-4-diethylaminobutylamino)acridine, 6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridineDental Mesenchymal Pulp Stem Cells
go.drugbank.com/drugs/DB15737InvestigationalDPSCs can remain stable in media once extracted, and have a high proliferation and regeneration capacity. … They also express specific pluripotency markers like MYC and SOX2 which can be absent in other MSCs.