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Felbamate
go.drugbank.com/drugs/DB00949ApprovedAlternatively, it is used to treat partial and generalized seizures associated with Lennox-Gastaut syndrome in children. It has a weak inhibitory effect on GABA receptor binding sites. … In particular, in the adult patient population, it can be employed to treat partial seizures (with and without generalization).
Synonyms: Carbamic acid 3-carbamoyloxy-2-phenyl-propyl ester, 2-phenyl-1,3-propanediol dicarbamateCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersRamucirumab
go.drugbank.com/drugs/DB05578ApprovedInvestigationalBy binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stimulated receptor phosphorylation and downstream ligand-induced proliferation, … permeability, and migration of human endothelial cells.
Categories: Vascular Endothelial Growth Factor Receptor 2 Antagonist, Amino Acids, Peptides, and ProteinsProducts: CYRAMZA 500 MG/50 ML İNFÜZYONLUK ÇÖZELTİ KONSANTRESİ İÇEREN FLAKON, 1 ADET, CYRAMZA 100MG/10 ML INFÜZYONLUK ÇÖZELTI KONSANTRESI IÇEREN FLAKON, 1 ADETTropicamide
go.drugbank.com/drugs/DB00809ApprovedTropicamide is an alkaloid atropine‐derived anticholinergic drug and a non‐selective antagonist of muscarinic acetylcholine (mACh) receptors. … [L32178] Oral tropicamide has been investigated as a potential drug to relieve sialorrhea in patients with Parkinson's Disease.[A229958]
Mixtures: MYDRIASERT 0,28 MG/5,4 MG GÖZ INSERTI ,10 INSERT, Mydrane 0,2 mg/ml + 3,1 mg/ml + 10 mg/ml InjektionslösungCategories: Heterocyclic Compounds, 1-Ring, Mydriatics and CycloplegicsAgalsidase beta
go.drugbank.com/drugs/DB00103ApprovedInvestigationalAgalsidase beta is a recombinant human α-galactosidase A similar to [agalsidase alfa]. … [A220228,A220233] Use of agalsidase beta has decreased in Europe, in favor of agalsidase alfa, after a contamination event in 2009.
Categories: Enzymes and Coenzymes, Alimentary Tract and MetabolismProducts: REPLAGAL 1 MG/ML IV İNFÜZYONLUK KONSANTRE ÇÖZELTİ, 1 ADET, FABRAZYME 35 MG İNFÜZYONLUK ÇÖZELTİ İÇİN KONSANTRE TOZ, 1 ADETNepafenac
go.drugbank.com/drugs/DB06802ApprovedInvestigationalNepafenac is a non-steroidal anti-inflammatory prodrug (NSAID) usually sold as a prescription eye drop. It is used to treat pain and inflammation associated with cataract surgery.
Synonyms: 2-amino-3-benzoylbenzeneacetamideCategories: Selective Cyclooxygenase 2 Inhibitors (NSAIDs)Calcitriol
go.drugbank.com/drugs/DB00136ApprovedInvestigationalNutraceutical[DB00146] undergoes hydroxylation to form calcitriol via 1α-hydroxylase (CYP27B1) activity [A26353]. Calcitriol is considered to be the most potent metabolite of vitamin D in humans [A3366]. … Calcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 1,25-dihydroxycholecalciferol, or 1alpha,25-dihydroxyvitamin D<sub>3</sub>, 1,25-dihydroxyvitamin
Categories: Vitamin D and Analogues, Alimentary Tract and MetabolismSynonyms: (1α,3β,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol, 1α,25(OH)2D3Ziprasidone
go.drugbank.com/drugs/DB00246ApprovedInvestigational[A180748] Although ziprasidone is classified as an atypical antipsychotic, it appears to have a lower incidence of metabolic adverse effects compared to other medications in the same class.[A190525] … Disorders such as schizophrenia and bipolar disorder can significantly impair mood, cognition, and behavior.
Categories: Adrenergic alpha-1 Receptor Antagonists, Heterocyclic Compounds, 1-RingProducts: Zeldox 10 mg/ml Suspension zum Einnehmen, ZELDOX 20 MG KAPSUL, 56 ADETFinerenone
go.drugbank.com/drugs/DB16165ApprovedInvestigational[A236544,L34739] Finerenone was granted FDA approval on 9 July 2021,[L34739] followed by the EMA approval on 11 March 2022.[L41449] … Finerenone, or BAY 94-8862, is a mineralocorticoid receptor antagonist indicated to reduce the risk of sustained decline in glomerular filtration rate, end stage kidney disease, cardiovascular death, heart
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 SubstratesProducts: KERENDİA 10 MG FİLM KAPLI TABLET, 98 ADET, KERENDİA 10 MG FİLM KAPLI TABLET, 28 ADETImiquimod
go.drugbank.com/drugs/DB00724ApprovedInvestigationalImiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist. Imiquimod is commonly used topically to treat warts on the skin of the genital and anal areas. … Miquimod is also used to treat a skin condition of the face and scalp called actinic keratoses and certain types of skin cancer called superficial basal cell carcinoma.
Synonyms: 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine, 4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinolineMixtures: Imiquimod 5% / Levocetirizine Dihydrochloride 1% / Niacinamide 2%, Imiquimod 5% / Levocetirizine Dihydrochloride 1% / Tretinoin 0.05%Alirocumab
go.drugbank.com/drugs/DB09302ApprovedInvestigationaldiet and statin treatment. … The FDA approval was contingent on the completion of further clinical trials to better determine efficacy and safety. PCSK9 inhibition facilitates more LDL-C clearance from the blood.
Categories: Amino Acids, Peptides, and Proteins, Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) InhibitorsProducts: PRALUENT 150 MG/ML SC ENJEKSIYONLUK ÇÖZELTI IÇEREN KULLANIMA HAZIR ENJEKTÖR,1 ADET, PRALUENT 150 MG/ML SC ENJEKSIYONLUK ÇÖZELTI IÇEREN KULLANIMA HAZIR KALEM,1 ADET