Nepafenac

DB06802ApprovedInvestigationalSmall moleculeAnti-Inflammatory Agents, Non-Steroidal

Nepafenac is an ophthalmic NSAID used for the symptomatic treatment of pain and inflammation associated with cataract surgery. Nepafenac is a non-steroidal anti-inflammatory prodrug (NSAID) usually sold as a prescription eye drop.

Chemical structure of Nepafenac
Mechanism
Curator reviewed
Primary indication
For the treatment of pain and inflammation associated with cataract surgery.Curator reviewed · 2 structured indications
Formula / weight
C15H14N2O2 · 254.2839 g/mol (avg)
First approval
Canada, 2017 · United States, 2005 · European Union, 2020
Code names
AHR-9434 · AL-6515
Brand names
  • Ilevro
  • Nevanac

Resolves to

Compound
UNII0J9L7J6V8CCAS78281-72-8ChEMBLCHEMBL1021ChEBI75922PubChem151075KEGGD05143
Clinical / RWD
RxNorm298665ATCS01BC10PharmGKBPA165958407
Structure
InChIKeyQEFAQIPZVLVERP-UHFFFAOYSA-NSMILESNC(=O)CC1=CC=CC(C(=O)C2=CC=CC=C2)=C1N
Targets
P23219PTGS1P35354PTGS2

What you can answer from here — as of June 15, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
157Drug interactionsStructured to mechanism, not free text
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53Clinical trialsPhase, status and sponsor resolved per trial
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2Structured indicationsCondition, population, route and combination as fields, not prose
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1ContraindicationEach with its own population and attribute set
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37Marketed productsAcross 10 countries and 17 labellers
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1ATC codeIncluding every combination product, plus 21 drug categories
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12+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Nepafenac, and which of those have an active Phase 3 trial?

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