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Voclosporin
go.drugbank.com/drugs/DB11693ApprovedInvestigationalWithin 10 years of being diagnosed with SLE, 5-20% of those suffering from LN develop end-stage kidney disease, a fatal condition. … to older calcineurin inhibitors.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsMilnacipran
go.drugbank.com/drugs/DB04896ApprovedInvestigationalMilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment … Furthermore, in 2009 the US FDA approved milnacipran for the additional indication of treating fibromyalgia [F3925], although other regional regulatory authorities like the EMA, among others, have not
Categories: Milnacipran and enantiomer, Serotonin and Noradrenaline Reuptake InhibitorsBenign Prostatic Hyperplasia (BPH)
go.drugbank.com/conditions/DBCOND0033444Synonyms: Glandular, stromal and muscular hyperplasia of prostate gland, Glandular, stromal AND/OR muscular hyperplasia of prostate glandIopodic acid
go.drugbank.com/drugs/DB09333ApprovedWithdrawnThis drug was approved on March 15, 1962 but it is nowadays discontinued from the FDA and Health Canada. … On September 22, 1981, ipodate was submitted again by the company Schering AG but it is currently under an inactive status.[L1082]
Tiopronin
go.drugbank.com/drugs/DB06823ApprovedIt is similar to d-penicillamine in use and efficacy, but offers the advantage of far less adverse effects. … Tiopronin is used as a second-line therapy to control the rate of cystine precipitation and excretion, and prevent kidney stone formation.
Categories: Reducing and Complexing Thiol, Amino Acids, Peptides, and ProteinsDanaparoid
go.drugbank.com/drugs/DB06754ApprovedWithdrawnThe active constituents are heparan, dermatan and [DB09301] [T28], and they are isolated from the porcine intestinal mucosa [FDA Label]. … It is chemically distinct from heparin by containing different protein binding properties, thus has lower cross-reactivity in heparin-intolerant patients.
Categories: Heparin and similars, Blood and Blood Forming OrgansLevobetaxolol
go.drugbank.com/drugs/DB09351ApprovedIt was marketed as a 0.5% ophthalmic solution of levobetaxolol hydrochloride under the trade name Betaxon but has been discontinued.
Zanubrutinib
go.drugbank.com/drugs/DB15035ApprovedInvestigational[L39030] This indication is valid in the US, Europe, and Canada. … Zanubrutinib was granted accelerated approval by the FDA in November 2019 based on clinical trial results that demonstrated an 84% overall response rate from zanubrutinib therapy in patients with MCL,[
Categories: Antineoplastic and Immunomodulating AgentsProducts: CAPSULE 80MGEthinylestradiol
go.drugbank.com/drugs/DB00977ApprovedInvestigationalEthinylestradiol was first synthesized in 1938 by Hans Herloff Inhoffen and Walter Hohlweg at Schering.[A191107] It was developed in an effort to create an estrogen with greater oral bioavailability. … [A191107] These properties were achieved by the substitution of an ethinyl group at carbon 17 of [estradiol].[A191107] Ethinylestradiol soon replaced [mestranol] in contraceptive pills.
Mixtures: Alisma 2mg/35µg Filmtabletten, BELARA film-coated tablet 0.03mg/2mgCategories: Hormones and Related Agents, dienogest and ethinylestradiolPidolic acid
go.drugbank.com/drugs/DB03088ApprovedInvestigationalPidolic acid, in general, is found in large quantities in brain tissue and other tissues in bound form, like skin [L2729]. … Pidolic acid is a naturally occurring but little-studied amino acid derivative that can be formed enzymatically or non-enzymatically and participates as a biological intermediate with unique pharmacodynamics
Categories: Alimentary Tract and Metabolism, Amino Acids, Peptides, and Proteins