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Toremifene
go.drugbank.com/drugs/DB00539ApprovedInvestigationalToremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer.
Mixtures: FLOBACT - D, FLOBACT - DCategories: P-glycoprotein inhibitors, P-glycoprotein substratesBosentan
go.drugbank.com/drugs/DB00559ApprovedInvestigationalBosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals.
Synonyms: p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide, 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamideMixtures: OCUBRAX® SUSPENSION OFTALMICA, OCUBRAX® SUSPENSION OFTALMICADoxapram
go.drugbank.com/drugs/DB00561ApprovedInvestigationalVet approvedA central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)
Synonyms: 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinoneCategories: Heterocyclic Compounds, 1-RingCisatracurium
go.drugbank.com/drugs/DB00565ApprovedInvestigational[A243416,A253592] Cisatracurium is an R-cis-R-cis isomer of [atracurium] and has approximately 3 times its neuromuscular blocking potency. … [A243416] Compared to atracurium, cisatracurium produces a lower degree of histamine release.[A253597]
Synonyms: (1r,2r,1'r,2'r)-2,2'-{pentane-1,5-diylbis[oxy(3-oxopropane-3,1-diyl)]}bis[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium]Categories: Heterocyclic Compounds, 2-RingFenoprofen
go.drugbank.com/drugs/DB00573ApprovedAn anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.
Synonyms: 2-(3-phenoxyphenyl)propionic acid, 2-(m-phenoxyphenyl)propionic acidCategories: Non COX-2 selective NSAIDSValaciclovir
go.drugbank.com/drugs/DB00577ApprovedInvestigationalValacyclovir is the L-valine ester of aciclovir. It is a member of the purine (guanine) nucleoside analog drug class [F3949]. … Genital herpes is a frequently diagnosed sexually transmitted disease which currently affects more than 400 million individuals worldwide.
Synonyms: L-Valine, 2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)ethyl ester, L-Valine ester with 9-((2-hydroxyethoxy)methyl)guanineCategories: Heterocyclic Compounds, 2-RingPiperazine
go.drugbank.com/drugs/DB00592ApprovedVet approvedWithdrawnOutside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. … Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingProducts: PIPOL® JARABE, PIPOL ® JARABEMetaraminol
go.drugbank.com/drugs/DB00610ApprovedIt has been used primarily as a vasoconstrictor in the treatment of hypotension.
Synonyms: 1-(m-Hydroxyphenyl)-2-amino-1-propanol, 2-Amino-1-(m-hydroxyphenyl)-1-propanolCategories: Adrenergic alpha-1 Receptor AgonistsBisoprolol
go.drugbank.com/drugs/DB00612ApprovedInvestigational[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. … Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.
Synonyms: (+-)-1-((alpha-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol, (RS)-1-(4-(2-Isopropoxyethoxymethyl)phenoxy)-3-(isopropylamino)-2-propanolMixtures: ZIAC ® 5 MG, CORBIS® DAmodiaquine
go.drugbank.com/drugs/DB00613ApprovedInvestigationalA 4-aminoquinoquinoline compound with anti-inflammatory properties.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates