Doxapram

DB00561ApprovedInvestigationalVet approvedSmall moleculeRespiratory System Agents

Doxapram is a short acting respiratory stimulant used to treat acute respiratory insufficiency in COPD patients. A central respiratory stimulant with a brief duration of action.

Chemical structure of Doxapram
Mechanism
Curator reviewed
Primary indication
For use as a temporary measure in hospitalized patients with acute respiratory insufficiency superimposed on chronic obstructive pulmonary disease.Curator reviewed · 5 structured indications
Formula / weight
C24H30N2O2 · 378.5072 g/mol (avg)
First approval
Canada, 1992 · United States, 1965
Brand names
  • Dopram

Resolves to

Compound
UNII94F3830Q73CAS309-29-5ChEMBLCHEMBL1754ChEBI681848PubChem3156KEGGD07873
Clinical / RWD
RxNorm3637ATCR07AB01PharmGKBPA164784026
Structure
InChIKeyXFDJYSQDBULQSI-UHFFFAOYSA-NSMILESCCN1CC(CCN2CCOCC2)C(C1=O)(C1=CC=CC=C1)C1=CC=CC=C1
Targets
O14649KCNK3Q9NPC2KCNK9

What you can answer from here — as of September 23, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
543Drug interactionsStructured to mechanism, not free text
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10Clinical trialsPhase, status and sponsor resolved per trial
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5Structured indicationsCondition, population, route and combination as fields, not prose
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16ContraindicationsEach with its own population and attribute set
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7Marketed productsAcross 3 countries and 7 labellers
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1ATC codeIncluding every combination product, plus 7 drug categories
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10+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Doxapram, and which of those have an active Phase 3 trial?

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