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MK-0731
go.drugbank.com/drugs/DB08037InvestigationalMK-0731 is a kinesin spindle protein inhibitor and antineoplastic agent.
Revumenib
go.drugbank.com/drugs/DB18515ApprovedInvestigationalAbnormal gene rearrangements at chromosome locus 11q23, called KMT2A rearrangements or translocations, are present in 5%-10% of patients with acute leukemias and are the sole genetic aberration found in … [L51888] In October of 20225, it was approved for myeloid leukemia patients with nucleophosmin 1 (NPM1) mutations. [L54376]
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsSynonyms: Benzamide, n-ethyl-2-((4-(7-((trans-4-((ethylsulfonyl)amino)cyclohexyl)methyl)-2,7-diazaspiro(3.5)non-2-yl)-5-pyrimidinyl)oxy)-5-fluoro-n-(1-methylethyl)-Osilodrostat
go.drugbank.com/drugs/DB11837ApprovedInvestigationalhas not been curative. … [L12123] It has undergone phase II clinical trials for the treatment of solid tumours, hypertension, and heart failure, but development for these indications was discontinued by Novartis in January 2013
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsAminophenazone
go.drugbank.com/drugs/DB01424ApprovedWithdrawnIn biomedical applications, radiolabelled (13C-labeled) aminophenazone has been used in breath tests to measure the cytochrome P-450 metabolic activity in liver function tests.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesSynonyms: 1-Phenyl-2,3-dimethyl-4-(dimethylamino)-5-pyrazolone, 1-Phenyl-2,3-dimethyl-4-dimethylaminopyrazol-5-oneMilsaperidone
go.drugbank.com/drugs/DB24348ApprovedInvestigational[A275426, A202004] Similarly, milsaperidone acts as an antagonist at dopamine D2 and 5-HT2A receptors,[A275427] as well as other adrenergic, dopamine, and serotonin receptor subtypes. … [L56056] On February 20, 2026, milsaperidone was approved by the FDA for the treatment of Bipolar I Disorder and schizophrenia.[L56059]
Categories: Serotonin 5-HT1 Receptor Antagonists, Serotonin 5-HT2 Receptor AntagonistsChamaemelum nobile flower
go.drugbank.com/drugs/DB14328InvestigationalChamaemelum nobile flower is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Mixtures: DENTINOX 3.4 MG/G + 3.2 MG/G + 150 MG/G JEL, 10 G, DENTINOX 3.4 MG/G + 3.2 MG/G + 150 MG/G JEL, 20 GJaktinib
go.drugbank.com/drugs/DB17545InvestigationalJaktinib is under investigation in clinical trial NCT04866056 (Jaktinib and Azacitidine in Treating Patients With MDS With MF or MDS/MPN With MF.).
BHV-1300
go.drugbank.com/drugs/DB22673InvestigationalBHV-1300 is a IgG<sub>1,2,4</sub> selective degrader being investigated for the treatment of Grave's disease.
Sunvozertinib
go.drugbank.com/drugs/DB18925Investigationalreceptor (EGFR) exon 20 insertion mutations. … [A274143] Sunvozertinib was granted accelerated approval in the US on July 2, 2025 for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 InducersSynonyms: 2-Propenamide, N-[5-[[4-[[5-chloro-4-fluoro-2-(1-hydroxy-1- methylethyl)phenyl]amino]-2-pyrimidinyl]amino]-2-[(3R)-3-(dimethylamino)-1-pyrrolidinyl]-4-methoxyphenyl]-, N-{5-[(4-{[5-chloro-4-fluoro-2-(1-hydroxy-1-methylethyl)phenyl]amino}pyrimidin-2-yl)amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl}prop-2-enamideGVAX
go.drugbank.com/drugs/DB17276InvestigationalGVAX is a granulocyte-macrophage colony-stimulating factor (GM-CSF) gene-transfected tumor cell vaccine.
Synonyms: Replication-incompetent GM-CSF-expressing gene-modified allogeneic pancreatic cancer cell lines, Replication-incompetent GM-CSF-expressing gene-modified allogeneic acute myeloid leukemia cancer cell lines