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Azelastine
go.drugbank.com/drugs/DB00972ApprovedInvestigational[L8240,L8270] It is a racemic mixture, though there is no noted difference in pharmacologic activity between enantiomers, and was first granted FDA approval in 1996. … allergic rhinitis in patients 6 years of age and older.
Synonyms: 4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1-(2H)-phthalazinoneMixtures: N-S-4, ALERXY® CGadobenic acid
go.drugbank.com/drugs/DB00743ApprovedInvestigational[A263166] As gadobenate dimeglumine is specifically taken up by hepatocytes and excreted through the biliary system, it is a useful contrast agent for liver MRI. … [A263086] It differs from other GBCAs due to the benzene ring that confers weak protein binding, thus leading to an increased R1 and R2 relaxivity.
Categories: Compounds used in a research, industrial, or household settingProducts: MULTIHANCE TEK DOZLUK IV ENJEKSIYONLUK COZELTI ICEREN FLAKON, 5 ML, MultiHance 0,5 mmol/ml Injektionslösung in einer FertigspritzeNF-kappa-B inhibitor alpha
go.drugbank.com/bio_entities/BE0003469TargetHumansInhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals (PubMed:1493333, PubMed:36651806, PubMed:7479976). On cellular stimu...
Synonyms: I-kappa-B-alphaFlibanserin
go.drugbank.com/drugs/DB04908ApprovedInvestigationalIt was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder drug by Sprout Pharmaceuticals … in the brain as well as an effect on increasing norepinephrine and dopamine neurotransmitters.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Cytochrome P-450 SubstratesLorlatinib
go.drugbank.com/drugs/DB12130ApprovedInvestigationalIt was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-positive non-small cell lung cancer, followed by an expanded approval in 2022 to … Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer[L39905] which was first approved by the US FDA in November of 2018
Categories: MATE 1 Inhibitors, P-glycoprotein inducersProducts: LORBRENA® 25 MG, LORBRENA® 100 MGGlucarpidase
go.drugbank.com/drugs/DB08898ApprovedInvestigational[A244750] Glucarpidase is an enzyme that can rapidly hydrolyze methotrexate into its nontoxic metabolites. … This can lead to delayed renal clearance of methotrexate and elevated drug plasma levels, increasing the risk of methotrexate toxicity.
Cardiolipin Biosynthesis CL(i-12:0/i-12:0/i-12:0/i-15:0)
smpdb.ca/view/SMP0051179DiseaseBTHS patients seem to lack acyl specificity and consequently, many potential cardiolipin species can exist (PMID: 16226238). … (Wikipedia) Cardiolipin biosynthesis occurs mainly in the mitochondria, but there also exists an alternative synthesis route for CDP-diacylglycerol that takes place in the endoplasmic reticulum.
Cardiolipin Biosynthesis CL(i-12:0/i-12:0/i-12:0/i-21:0)
smpdb.ca/view/SMP0051185DiseaseBTHS patients seem to lack acyl specificity and consequently, many potential cardiolipin species can exist (PMID: 16226238). … (Wikipedia) Cardiolipin biosynthesis occurs mainly in the mitochondria, but there also exists an alternative synthesis route for CDP-diacylglycerol that takes place in the endoplasmic reticulum.
Cardiolipin Biosynthesis CL(i-12:0/i-12:0/i-12:0/i-22:0)
smpdb.ca/view/SMP0051186DiseaseBTHS patients seem to lack acyl specificity and consequently, many potential cardiolipin species can exist (PMID: 16226238). … (Wikipedia) Cardiolipin biosynthesis occurs mainly in the mitochondria, but there also exists an alternative synthesis route for CDP-diacylglycerol that takes place in the endoplasmic reticulum.
Cardiolipin Biosynthesis CL(i-12:0/i-12:0/i-13:0/i-13:0)
smpdb.ca/view/SMP0051195DiseaseBTHS patients seem to lack acyl specificity and consequently, many potential cardiolipin species can exist (PMID: 16226238). … (Wikipedia) Cardiolipin biosynthesis occurs mainly in the mitochondria, but there also exists an alternative synthesis route for CDP-diacylglycerol that takes place in the endoplasmic reticulum.