NF-kappa-B inhibitor alpha

BE0003469ProteinHumansNFKBIA

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals (PubMed:1493333, PubMed:36651806, PubMed:7479976). It is acted on by 5 drugs in DrugBank.

Gene name
NFKBIA
UniProtKB entry
P25963Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
317 residues · 35,609 Da
Also known as
I-kappa-B-alpha · IkappaBalpha · IkB-alpha · IKBA · MAD3

Resolves to

Protein
UniProtP25963UniProt nameIKBA_HUMAN
Gene
HGNCHGNC:7797NCBI Gene4792GeneCardsNFKBIA
Pharmacology
KEGGhsa:4792
Structure
PDB1IKNPDB1NFIPDB6TTU
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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36+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NF-kappa-B inhibitor alpha, how selective are they, and which programs against it are still in active trials?

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