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Carvedilol
go.drugbank.com/drugs/DB01136ApprovedInvestigationalCarvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker. … [A182306] Carvedilol was granted FDA approval on 14 September 1995.[L7889]
Mixtures: Co-Dilatrend 25 mg/12,5 mg - Filmtabletten, CARIVALAN 25/5Categories: Adrenergic alpha-1 Receptor Antagonists, Adrenergic beta-1 Receptor AntagonistsHydrochlorothiazide
go.drugbank.com/drugs/DB00999ApprovedInvestigationalVet approved[L7426,L7459] Hydrochlorothiazide was granted FDA approval on 12 February 1959.[L8444] … [A185138] Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors[L8390,L8423] or angiotensin II receptor blockers.
Mixtures: Ramipril/Amlodipin/HCT 1A Pharma 10 mg/5 mg/25 mg – Hartkapseln, Ramipril/Amlodipin/HCT Genericon 10 mg/5 mg/25 mg HartkapselnCategories: Heterocyclic Compounds, 2-Ring, hydrochlorothiazide and potassiumBupropion
go.drugbank.com/drugs/DB01156ApprovedInvestigationalPOMC auto-inhibition, which are associated with a reduction in food intake and increased energy expenditure. … [L6562,A179038,A179050] The combination of naltrexone and bupropion was shown to result in a statistically significant weight loss, with a mean change in body weight of -6.3% compared to -1.3% for placebo
Mixtures: Appbutamone-D, Naltrexone Hydrochloride and Bupropion Hydrochloride Extended-ReleaseCategories: bupropion and naltrexone, bupropion and dextromethorphanUlipristal
go.drugbank.com/drugs/DB08867ApprovedInvestigationalIt is a derivative of 19-norprogesterone and has both antagonistic and partial agonist activity at the progesterone receptor. … It also binds to glucocorticoid receptor, however compared to mifepristone (a progesterone receptor antagonist), ulipristal is more tolerable and has lower glucocorticoid activity and better binding affinity
Categories: Genito Urinary System and Sex Hormones, Sex Hormones and Modulators of the Genital SystemProducts: ESMYA® 5 MG COMPRIMIDOS, JOSEİ 30 MG TABLET, 1 ADETIDN-7314
go.drugbank.com/drugs/DB18073ExperimentalSynonyms: (s)-3-((s)-2-(2-((2,6-difluorophenyl)amino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid, L-alaninamide, n-(2,6-difluorophenyl)-2-oxoglycyl-n-((1s)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl)-Poractant alfa
go.drugbank.com/drugs/DB09113ApprovedInvestigationalPoractant alfa is an extract of natural porcine lung surfactant consisting of 99% polar lipids (mainly phospholipids) and 1% hydrophobic low molecular weight proteins (surfactant associated proteins SP-B … and SP-C).
Products: CUROSURF 120 MG/1,5 ML INTRATRAKEAL SUSPANSIYON IÇEREN FLAKON, 1 ADET, CUROSURF 240 MG/3 ML INTRATRAKEAL SUSPANSIYON IÇEREN FLAKON, 1 ADETLicaminlimab
go.drugbank.com/drugs/DB18936InvestigationalLicaminlimab is under investigation in clinical trial NCT05896670 (Safety and Efficacy of Licaminlimab Ophthalmic Suspension for the Treatment of Dry Eye Disease).
Synonyms: immunoglobulin scFv, anti-[Homo sapiens TNF (tumor necrosis factor, TNFSF2, DIF, TNF-alpha)], humanized monoclonal antibody single chain; IG scFv humanized single chain (V-KAPPA-VH) (1-254) [V-KAPPA (Homo, sapiens IGKV1-5*03 (79.2%) -(IGHD) -IGKJ2*02 (77.Chlorphenoxamine
go.drugbank.com/drugs/DB09007ApprovedWithdrawnIt is an antihistamine and anticholinergic used to treat itching as well as for its antiparkinsonian effect.
Synonyms: ETHENAMINE, 2-(1-(4-CHLOROPHENYL)-1-PHENYLETHOXY)-N,N-DIMETHYL-, 2-((P-CHLORO-.ALPHA.-METHYL-.ALPHA.-PHENYLBENZYL)OXY)-N,N-DIMETHYLETHYLAMINEMixtures: SISTRAL C DRAJE , 20 ADETDenosumab
go.drugbank.com/drugs/DB06643ApprovedInvestigationalTwo denosumab biosimilars—Wyost® (denosumab-bbdz) [L53063] and Jubbonti® (denosumab-bbdz)[L53058]—were approved by the FDA in March 2024 for all indications of the reference products Xgeva® and Prolia® … [A263071] Chemically, it consists of 2 heavy and 2 light chains, with each light chain consisting of 215 amino acids and each heavy chain consisting of 448 amino acids with 4 intramolecular disulfides.
Categories: Amino Acids, Peptides, and Proteins, Drugs Affecting Bone Structure and MineralizationProducts: XGEVA® 120 MG/1.7 ML, XGEVA 120 MG SC. ENJEKSIYONLUK COZELTI ICEREN FLAKON, 1 ADETFluvastatin
go.drugbank.com/drugs/DB01095ApprovedInvestigationalFluvastatin is a racemate comprising equimolar amounts of (3R,5S)- and (3S,5R)-fluvastatin. … Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase.
Categories: Cytochrome P-450 CYP2B6 Inducers, Cytochrome P-450 CYP1A1 SubstratesProducts: Lescol MR 80 mg - Filmtabletten, LESCOL XL TABLET 80 mg