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Tegafur
go.drugbank.com/drugs/DB09256ApprovedInvestigationalTegafur is usually given in combination with other drugs that enhance the bioavailability of the 5-FU by blocking the enzyme responsible for its degradation, or serves to limit the toxicity of 5-FU by … Tegafur (INN, BAN, USAN) is a prodrug of [DB00544] (5-FU), an antineoplastic agent used as the treatment of various cancers such as advanced gastric and colorectal cancers.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesInternational brands: ESUEEW AN TOxymorphone
go.drugbank.com/drugs/DB01192ApprovedVet approvedIt may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092). … An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesAsparaginase Erwinia chrysanthemi
go.drugbank.com/drugs/DB08886ApprovedInvestigational[A236344] Studies show that substitution of _Erwinia_ asparaginase for _E. coli_-derived asparaginase following an allergic reaction has been safe and effective. … Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent.
Everolimus
go.drugbank.com/drugs/DB01590ApprovedInvestigationalIt is currently used as an immunosuppressant to prevent rejection of organ transplants. … Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: Certican 0,1 mg - Tabletten zur Herstellung einer Suspension zum Einnehmen, Certican 0,25 mg - Tabletten zur Herstellung einer Suspension zum EinnehmenMetamfetamine
go.drugbank.com/drugs/DB01577ApprovedIllicitInvestigationalWithdrawnMethamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. … It is a scheduled drug in most countries due to its high potential for addiction and abuse.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesPH-797804
go.drugbank.com/drugs/DB07941InvestigationalPH-797804 has been investigated for the treatment of Osteoarthritis.
Efanesoctocog alfa
go.drugbank.com/drugs/DB16662ApprovedInvestigational[A257464,A257469] In February 2023, efanesoctocog alfa was approved by the FDA as a new class of factor VIII therapy for hemophilia A.[L45379,L45414] … Efanesoctocog alfa (BIVV001) is a recombinant factor VIII (FVIII) analogue fusion protein used for the routine prophylaxis, perioperative management of bleeding and on-demand treatment and control of bleeding
Mechlorethamine
go.drugbank.com/drugs/DB00888ApprovedInvestigationalThe FDA granted marketing approval for the orphan drug Valchlor (mechlorethamine) gel on August 23, 2013 for the topical treatment of stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma (CTCL … A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas.
Categories: Chemical Warfare AgentsThalidomide
go.drugbank.com/drugs/DB01041ApprovedInvestigationalWithdrawnIt has been reintroduced and used for a number of inflammatory disorders and cancers.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InducersInternational brands: Pro-ban M