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Displaying results 2971 - 2980 of 7284 in total
  1. Drug

    Caplacizumab

    go.drugbank.com/drugs/DB06081
    ApprovedInvestigational

    Caplacizumab was developed by Ablynx, a Sanofi company and FDA approved on February 6, 2019,[L5302] and approved previously by the EU in October 2018 as a combination therapy with plasma exchange and immunosuppression … Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of two identical humanized building blocks genetically linked by a three-alanine linker.

  2. Target

    NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

    go.drugbank.com/bio_entities/BE0000191
    TargetEnzymeHumans

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor … Essential for the catalytic activity and assembly of complex I (PubMed:14729820, PubMed:24028823, PubMed:30140060)

    Synonyms: Complex I-30kD
  3. Target

    NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

    go.drugbank.com/bio_entities/BE0000729
    TargetEnzymeHumans

    Essential for the catalytic activity of complex I (PubMed:22036843, PubMed:30922174). Essential for the assembly of complex I (By similarity). … Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor

    Synonyms: Complex I-49kD
  4. Target

    Protein SLC31A2

    go.drugbank.com/bio_entities/BE0003662
    TransporterHumans

    Does not function as a copper(1+) importer in vivo (By similarity). However, in vitro functions as a low-affinity copper(1+) importer (PubMed:17617060, PubMed:17944601). … export and modulates the copper and cisplatin accumulation via SLC31A1 (By similarity)

    Synonyms: Copper transporter 2Function: copper ion transmembrane transporter activity
  5. Drug

    Filgotinib

    go.drugbank.com/drugs/DB14845
    ApprovedInvestigational

    Rheumatoid arthritis (RA) is a chronic, autoimmune, systemic, and inflammatory disease that causes synovial joint symptoms and can limit range of motion in severe cases. … In contrast, the newly approved filgotinib is a highly selective JAK1 inhibitor.

  6. Drug

    Betrixaban

    go.drugbank.com/drugs/DB12364
    Approved

    Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa [A7708]. … It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity [A27286].

    Categories: Factor Xa Inhibitors, Direct factor Xa inhibitors
  7. Drug

    Tigemonam

    go.drugbank.com/drugs/DB20272
    Experimental

    Tigemonam is a small molecule drug. The usage of the INN stem '-monam' in the name indicates that Tigemonam is a monobactam antibiotic. Tigemonam has a monoisotopic molecular weight of 437.03 Da.

  8. Drug

    Hydroxytetracaine

    go.drugbank.com/drugs/DB20319
    Experimental

    Hydroxytetracaine has a monoisotopic molecular weight of 280.18 Da. … Hydroxytetracaine is a small molecule drug. The usage of the INN stem '-caine' in the name indicates that Hydroxytetracaine is a local anaesthetic.

  9. Drug

    Alimadol

    go.drugbank.com/drugs/DB20326
    Experimental

    Alimadol is a small molecule drug. The usage of the INN stem '-adol/-adol-' in the name indicates that Alimadol is a analgesic. Alimadol has a monoisotopic molecular weight of 281.18 Da.

  10. Drug

    Nuvenzepine

    go.drugbank.com/drugs/DB20349
    Experimental

    Nuvenzepine is a small molecule drug. The usage of the INN stem '-zepine' in the name indicates that Nuvenzepine is a tricyclic compound. Nuvenzepine has a monoisotopic molecular weight of 336.16 Da.