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Turoctocog alfa pegol
go.drugbank.com/drugs/DB14738ApprovedInvestigationalTuroctocog alfa is produced in Chinese hamster ovary (CHO) cells without addition of any human or animal-derived materials [F3685]. … Fundamentally, the N8-GP moiety is identical to [turoctocog alfa], a recombinant human clotting factor VIII (rFVIII) with a truncated B-domain made from the sequence coding for 10 amino acids from the
Categories: Amino Acids, Peptides, and ProteinsSusoctocog alfa
go.drugbank.com/drugs/DB11606ApprovedInvestigationalThese autoantibodies neutralize circulating human factor VIII and create a functional deficiency of this procoagulant protein. … The recombinant porcine sequence allows less susceptibility to inactivation by circulating human factor VIII antibodies.
Categories: Blood and Blood Forming OrgansD-alpha-Tocopherol acetate
go.drugbank.com/drugs/DB14002ApprovedNutraceuticalVet approvedAlpha-tocopherol is the primary form of vitamin E that is preferentially used by the human body to meet appropriate dietary requirements. … of different conditions like cardiovascular disease, ocular conditions, diabetes, cancer and more.
Mixtures: Multi Vitamin and Mineral vitamin, Iron With Vitamins C and E - TabCategories: Diet, Food, and NutritionRamucirumab Action Pathway
smpdb.ca/view/SMP0126890Drug actionIt is a human monoclonal antibody (IgG1) designed against VEGFR2, a transmembrane tyrosine kinase receptor expressed on endothelial cells. … , and migration of endothelial cells.
Enzymes: Thrombin, Fibrinogen beta chainDanaparoid
go.drugbank.com/drugs/DB06754ApprovedWithdrawnThe active constituents are heparan, dermatan and [DB09301] [T28], and they are isolated from the porcine intestinal mucosa [FDA Label]. … Danaparoid sodium is the common salt form in therapeutic preparations and is typically administered subcutaneously.
Categories: Heparin and similars, Blood and Blood Forming OrgansNafamostat
go.drugbank.com/drugs/DB12598InvestigationalIt has been used in trials studying the prevention of Liver Transplantation and Postreperfusion Syndrome. … The use of nafamostat in Asian countries is approved as an anticoagulant therapy for patients undergoing continuous renal replacement therapy due to acute kidney injury.
Alteplase Action Pathway
smpdb.ca/view/SMP0126634Drug actionAlteplase is a recombinant plasminogen activator present in human tissue, also known as Activase, Cathflo and Cathflo Activase used to treat emergencies such as myocardial infarction, ischemic stroke and … Due to its nature of anticoagulant and antiplatelet activity herbs and supplements with similar activity should be avoided such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba.
Enzymes: Thrombin, Fibrinogen beta chainReteplase Action Pathway (new)
smpdb.ca/view/SMP0126637Drug actionReteplase is a plasminogen activator that is created as a purified form of human tissue, also known as Retavase that is used in emergencies such as myocardial infarction, ischemic stroke and pulmonary … Reteplase is administered intravenously and travels through the bloodstream and acts on plasminogen cleaving an arginine-valine bond converting it to its active form plasmin.
Enzymes: Thrombin, Fibrinogen beta chainAnistreplase Action Pathway (new)
smpdb.ca/view/SMP0126638Drug actionAnistreplase is a plasminogen activator created from recombinant human tissue, used in emergencies such as myocardial infarction and pulmonary emboli. … Due to its anticoagulant and antiplatelet activity, avoid herbs and supplements with similar activity such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba.
Enzymes: Thrombin, Fibrinogen beta chainTenecteplase Action Pathway (new)
smpdb.ca/view/SMP0126640Drug actionTenecteplase is a plasminogen activator, a modified form of recombinant human tissue, also known as Metalyse and Tnkase, used in emergencies such as myocardial infarction and pulmonary emboli. … Due to its anticoagulant and antiplatelet activity herbs and supplements with similar activity should be avoided such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba.
Enzymes: Thrombin, Fibrinogen beta chain