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Displaying results 291 - 300 of 1809 in total
  1. Target

    Cannabinoid receptor

    go.drugbank.com/bio_entities/BE0010258
    TargetHumans

    Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. … G protein-coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such

    Polypeptides: Cannabinoid receptor 1, Cannabinoid receptor 2Function: cannabinoid receptor activity, cannabinoid receptor activity
  2. Target

    Folate receptor

    go.drugbank.com/bio_entities/BE0010260
    TransporterTargetHumans

    Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release … Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (PubMed:8567728).

    Polypeptides: Folate receptor alpha, Folate receptor betaSynonyms: Folate receptor 1, Folate receptor 2
  3. Target

    Adenosine receptor

    go.drugbank.com/bio_entities/BE0010284
    TargetHumans

    Upon adenosine binding, mediates cardioprotection in cardiomyocytes through anti-apoptotic effects primarily via the ERK1/2 pathway as well as the PI3K pathway (PubMed:9837869). … Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

    Polypeptides: Adenosine receptor A1, Adenosine receptor A2aFunction: G protein-coupled adenosine receptor activity, G protein-coupled adenosine receptor activity
  4. Target

    Apelin receptor

    go.drugbank.com/bio_entities/BE0013166
    TargetHumans

    G protein-coupled receptor for peptide hormones apelin (APLN) and apelin receptor early endogenous ligand (APELA/ELA), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis … When acting as apelin receptor, activates both G(i) protein pathway that inhibits adenylate cyclase activity, and the beta-arrestin pathway that promotes internalization of the receptor (PubMed:11090199

    Polypeptides: Apelin receptorSynonyms: Angiotensin receptor-like 1, G protein-coupled receptor APJ
  5. Drug

    Acetazolamide

    go.drugbank.com/drugs/DB00819
    ApprovedInvestigationalVet approved

    One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizur...

  6. Drug

    Tavolixizumab

    go.drugbank.com/drugs/DB15042
    Investigational

    Tavolixizumab is under investigation in clinical trial NCT02318394 (A Phase 1 Study of MEDI0562 in Adult Subjects With Selected Advanced Solid Tumors).

    Synonyms: IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENSTNFRSF4 (TUMOR NECROSIS FACTOR RECEPTOR (TNFR) SUPERFAMILY MEMBER 4, OX40, CD134)), HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODY GAMMA1 HEAVY CHAIN (1-451) (CHIMERIC
  7. Drug

    Dextrothyroxine

    go.drugbank.com/drugs/DB00509
    ApprovedWithdrawn

    Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin.

  8. Indication

    Locally Advanced Unresectable Hormone Receptor-Positive Breast Carcinoma

    go.drugbank.com/conditions/DBCOND0162925
    Drugs: Sacituzumab govitecan
    Synonyms: Locally Advanced Unresectable Hormone Receptor-Positive Breast Carcinoma, Unresectable, locally advanced Hormone Receptor Positive Breast Carcinoma
  9. Drug

    Drotaverine

    go.drugbank.com/drugs/DB06751
    ApprovedWithdrawn

    Drotaverine is an antispasmodic drug that works by inhibiting phosphodiesterase-4 (PDE4). It is a benzylisoquinoline derivative that is structurally related to papaverine, although it displays more potent antispasmodic activities than pa...

  10. Drug

    Alfentanil

    go.drugbank.com/drugs/DB00802
    ApprovedIllicitInvestigational

    A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analges...