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Hyperglycemia
go.drugbank.com/conditions/DBCOND0020377Synonyms: High Level of Sugar (Glucose) in the BloodEnmetazobactam
go.drugbank.com/drugs/DB18716ApprovedInvestigational[A263266] Because ESBL enzymes can hydrolyze important antibiotics such as penicillins, broad-spectrum cephalosporins and monobactams, ESBL-producing bacteria poses challenges in the treatment of serious … [A263276] The combination product of enmetazobactam and [cefepime] was first approved by the FDA on February 23, 2024, for the treatment of complicated urinary tract infections.
Abaloparatide
go.drugbank.com/drugs/DB05084ApprovedInvestigational[L740] It was first approved by the FDA on April 28, 2017,[A256748] for the treatment of osteoporosis in postmenopausal women and is also used to increase bone density in men with osteoporosis. … Abaloparatide is an N-terminal analog of parathyroid hormone-related protein (PTHrP) [A256778] and an agonist at the parathyroid hormone type 1 (PTH1) receptor.
Categories: Sex Hormones and Insulins, Amino Acids, Peptides, and ProteinsRelebactam
go.drugbank.com/drugs/DB12377ApprovedInvestigational[A181207] It is currently available in a combination product which includes [imipenem] and [cilastatin] to treat complicated urinary tract infections (UTIs), pyelonephritis, and complicated intra-abdominal … [A181195,A181207] It includes a piperidine ring which reduces export from bacterial cells by producing a positive charge.
Categories: imipenem, cilastatin and relebactamNatural Killer Cell
go.drugbank.com/drugs/DB15721InvestigationalOther techniques involve using umbilical cord blood (UCB) directly; these NK cells have heterogeneous CD56 expression but are considered suitable for immunotherapy. … It is also possible to culture UCB CD34+ hematopoietic stem cells (HSCs) under stimulation of IL-2, IL-15, and stem cell factor (SCF) in a system to develop NK cells.
Synonyms: NK CellsDeutivacaftor
go.drugbank.com/drugs/DB15141ApprovedInvestigational[L52275,A179677] Deutivacaftor was first approved by the US FDA in December 2024 in combination with two CFTR correctors - [tezacaftor] and [vanzacaftor] - for the treatment of patients with responsive … It is used alongside CFTR correctors to increase the quantity and function of CFTR at the cell surface in patients with cystic fibrosis.
Categories: deutivacaftor, tezacaftor and vanzacaftorBarbexaclone
go.drugbank.com/drugs/DB09001ExperimentalBarbexaclone exists in 25mg and 100mg tablets. 100mg of barbexaclone is equivalent to 60mg of phenobarbital. … These reports were conducted in a small series of patients in the 1970s and 1980s, and have yet to be confirmed by larger controlled trials.
Categories: Barbiturates and DerivativesAtogepant
go.drugbank.com/drugs/DB16098ApprovedInvestigationalIt was developed by AbbVie and received FDA approval under the brand name Qulipta in September 2021. … novel in that it is the first and only oral CGRP antagonist approved for preventative use in migraine.
Dronedarone
go.drugbank.com/drugs/DB04855ApprovedInvestigational[T28] Commonly marketed as Multaq®, dronedarone was approved by the FDA in July 2009 and Health Canada in August 2009. … It is managed by rate control, rhythm control, prevention of thromboembolic events, and treatment of the underlying disease.
Synonyms: N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)-methanesulfonamide, N-(2-butyl-3-(p-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)methanesulfonamideProducts: Film-coated Tablet 400mgLevopropoxyphene
go.drugbank.com/drugs/DB06793ApprovedWithdrawnLevopropoxyphene is a stereoisomer of propoxyphene in the form of 2S, 3R enantiomer. It was sold as an antitussive, but it was removed from the market in the 70s. … [T133] Levopropoxyphene was developed by Lilly and FDA approved on March 21st, 1962. This drug presented different dosages and it was administered as a capsule or suspension.