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Displaying results 3061 - 3070 of 10000 in total
  1. Drug

    Olodaterol

    go.drugbank.com/drugs/DB09080
    ApprovedInvestigational

    Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. … It is by this mechanism that olodaterol is used for the treatment of chronic obstructive pulmonary disease (COPD) and the progressive airflow obstruction that is characteristic of it.

    Categories: olodaterol and tiotropium bromide
  2. Drug

    Recombinant stabilized RSV A prefusion F antigen

    go.drugbank.com/drugs/DB18713
    ApprovedInvestigational

    of an adjuvant. … [L48066] Abrysvo was first approved by the FDA in May 2023 for use in patients ≥60 years of age, and received subsequent approval in August 2023 for use in pregnant individuals for the protection of

  3. Drug

    Hyoscyamine

    go.drugbank.com/drugs/DB00424
    ApprovedInvestigational

    Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine].[A228423] It is commonly extracted from plants in the _Solanaceae_ or nightshade family. … [A228713] Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimuscarinic properties.

    Mixtures: UR N-C Urinary Antiseptic, Diban CapCategories: Alimentary Tract and Metabolism, hyoscyamine and psycholeptics
  4. Drug

    Insulin beef

    go.drugbank.com/drugs/DB09456
    Approved

    Insulin beef has been discontinued in the US and Canada since 2017.[L10827]

    Categories: Drugs Used in Diabetes, Alimentary Tract and Metabolism
  5. Drug

    Propiolactone

    go.drugbank.com/drugs/DB09348
    ApprovedWithdrawn

    [A32144] It is currently FDA approved for its use as an indirect additive used in food contact substances. Propiolactone was first commercially available in the United States in 1958.[A32144] … Propiolactone is a disinfectant used for the sterilization of blood plasma, vaccines, tissue grafts, surgical instruments, and enzymes. It has been used against bacteria, fungi, and virus.

    Categories: Compounds used in a research, industrial, or household setting
  6. Drug

    Anagrelide

    go.drugbank.com/drugs/DB00261
    ApprovedInvestigational

    [L14153] It is an oral imidazoquinazoline that was first approved for use in the US in 1997.[A214274] It appears to carry a better response rate than other thrombocythemia treatments (e.g. … [busulfan], [hydroxyurea]) and may be better tolerated.[A214274]

    Categories: Antineoplastic and Immunomodulating Agents
  7. Target

    Nuclear factor NF-kappa-B p105 subunit

    go.drugbank.com/bio_entities/BE0001086
    TargetHumans

    The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. … The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity

    Synonyms: Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
  8. Drug

    Epcoritamab

    go.drugbank.com/drugs/DB16672
    ApprovedInvestigational

    Epcoritamab is an IgG1-bispecific antibody that simultaneously binds to CD3 on T-cells and CD20 on B-cells. … Although this regimen is effective in up to 60% of patients, patients with relapsed or refractory DLBCL have poor outcomes.

    Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating Agents
  9. Drug

    N-alkyl ethylbenzyl dimethyl ammonium (C12-C14)

    go.drugbank.com/drugs/DB11202
    Approved

    It is found in sanitizing solutions or soaps as an active ingredient due to its antimicrobial properties. … Employed in a great variety of cleaning agents and sanitizing agents, it possesses relatively broad gram-positive and gram-negative antibacterial activities and relatively little chance for systemic absorption

    Synonyms: N-alkyl ethylbenzyl dimethyl ammonium (C12-C14), N-alkyl ethylbenzyl dimethyl ammonium (C12-C14) cationSalts: N-alkyl ethylbenzyl dimethyl ammonium chloride (C12-C14)
  10. Drug

    Mipomersen

    go.drugbank.com/drugs/DB05528
    Approved

    Mipomersen is indicated in patients with homozygous familial hypercholesterolemia as an adjunct to diet and other lipid-lowering medications. … Specifically, elevations in the liver enzymes, i.e. transaminases, and in liver fat (hepatic steatosis) have been reported.

    Categories: Nucleic Acids, Nucleotides, and Nucleosides, Compounds used in a research, industrial, or household setting