Nuclear factor NF-kappa-B p105 subunit

BE0001086ProteinHumansNFKB1

NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many... It is acted on by 24 drugs in DrugBank.

Gene name
NFKB1
UniProtKB entry
P19838Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
968 residues · 105,355 Da
Also known as
DNA-binding factor KBF1 · EBP-1 · Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

Resolves to

Protein
UniProtP19838UniProt nameNFKB1_HUMAN
Gene
HGNCHGNC:7794NCBI Gene4790GenBank189180GeneCardsNFKB1
Pharmacology
KEGGhsa:4790
Structure
PDB1MDIPDB1MDJPDB1MDK
Drugs

What you can answer from here — as of September 07, 2019

24DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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30GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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63+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Nuclear factor NF-kappa-B p105 subunit, how selective are they, and which programs against it are still in active trials?

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