Propiolactone is a lactone compound with a four-membered ring. It is a colorless liquid with a pungent slightly sweet odor. Propiolactone is a disinfectant used for the sterilization of blood... Propiolactone is a disinfectant used for the sterilization of blood plasma, vaccines, tissue grafts, surgical instruments, and enzymes.
- Mechanism
- Curator reviewed · 2 references
Propiolactone is an alkylating agent that acts through alkylation of carboxyl- and hydroxyl- groups. The lactone ring splits either at the first or third carbon. Propiolactone reacts with polynucleotides and DNA, mainly at N7 of guanine and N1 of adenine to form carboxyethyl derivatives. It also forms adducts with N3 of cytosine and thymine.
- Primary indication
- Propiolactone was used for vaccines, tissue grafts, surgical instruments, and enzymes, as a sterilant of blood plasma, water, milk and nutrient broth as a vapor-phase disinfectant in enclosed spaces.Curator reviewed
- Formula / weight
- C3H4O2 · 72.063 g/mol (avg)
- Also known as
- 1,3-propiolactone · 3-propanolide · beta-Propiolactone
- Code names
- NSC-21626
Resolves to
VEZXCJBBBCKRPI-UHFFFAOYSA-NSMILESO=C1CCO1What you can answer from here — as of February 21, 2021
Which companies are running trials of Propiolactone, in which indications and phases, and which of those programs are still active?
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