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Displaying results 3071 - 3080 of 10000 in total
  1. Drug

    Autologous cultured chondrocytes

    go.drugbank.com/drugs/DB10997
    ApprovedInvestigational

    It has been used since 1995 as Carticel and gained biologic license in 1997. The surgical implantation was first performed in Sweden. … It serves as an alternative repair treatment for patients with inadequate response to pre-existing surgical methods.

  2. Drug

    Ordesekimab

    go.drugbank.com/drugs/DB16649
    Investigational

    Ordesekimab is under investigation in clinical trial NCT02633020 (Study to Evaluate the Efficacy and Safety of AMG 714 in Adult Patients With Type II Refractory Celiac Disease).

  3. Drug

    Mespirenone

    go.drugbank.com/drugs/DB20625
    Experimental

    The usage of the INN stem '-renone' in the name indicates that Mespirenone is a mineralocorticoid receptor (MR, MCR, aldosterone receptor) antagonist. … Mespirenone has a monoisotopic molecular weight of 426.19 Da.

  4. Drug

    Crotalus atrox antivenin

    go.drugbank.com/drugs/DB13892
    Approved

    The majority of people bitten are males and about 50% occur in the age group of 18 to 28 [F113]. … Crotalus atrox antivenin is derived and purified immunoglobulin fragments obtained from other domestic animals such as sheep previously immunized with Crotalus atrox (Western Diamondback rattlesnake).

  5. Drug

    Bromchlorenone

    go.drugbank.com/drugs/DB20459
    Experimental

    The usage of the INN stem '-renone' in the name indicates that Bromchlorenone is a mineralocorticoid receptor (MR, MCR, aldosterone receptor) antagonist. … Bromchlorenone has a monoisotopic molecular weight of 246.9 Da.

  6. Drug

    Fomivirsen

    go.drugbank.com/drugs/DB06759
    ApprovedWithdrawn

    The drug was withdrawn by the FDA because while there was a high unmet need for drugs to treat CMV when the drug was initially discovered and developed due to the CMV arising in people with AIDS, the development … It was discovered by scientists at the National Institutes of Health (NIH) and was first developed by _Isis Pharmaceuticals_ and subsequently licensed to _Novartis_ [A31990].

  7. Drug

    Capivasertib

    go.drugbank.com/drugs/DB12218
    ApprovedInvestigational

    This approval is based on favorable results obtained from the CAPItello-291 trial, where the combination of capivasertib and [fulvestrant] reduced the risk of disease progression or death by 50% versus … Therefore, significant research has been put into developing genetically targeted treatments.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  8. Drug

    Ripretinib

    go.drugbank.com/drugs/DB14840
    ApprovedInvestigational

    Ripretinib, also known as Qinlock, is manufactured by Deciphera Pharmaceuticals and was initially approved by the FDA on May 15, 2020. … Ripretinib is a kinase inhibitor used for the treatment of advanced gastrointestinal stromal tumor (GIST) that has not adequately responded to other kinase inhibitors such as [sunitinib] and [imatinib]

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 Inhibitors
  9. Target

    Alternative prion protein

    go.drugbank.com/bio_entities/BE0008989
    TargetHumans

    Synonyms: PRIP
  10. Drug

    Gancotamab

    go.drugbank.com/drugs/DB14784
    Investigational

    Gancotamab is under investigation in clinical trial NCT02213744 (MM-302 Plus Trastuzumab vs.