Autologous cultured chondrocytes is a cell therapy used to treat damage to cartilage in the knees. It serves as an alternative repair treatment for patients with inadequate response to pre-existing surgical methods.
- Mechanism
- Curator reviewed
Chrondrocytes are collected from the patient's femoral articular cartilage and isolated cells are expanded through cell culture in vitro. Multiplied chrondrocytes are implanted into articular cartilage defects beneath an autologous periosteal flap. Cells produce hyaline-like cartilage that mainly consists of type II collagen. Type II collagen maintain the macromolecular framework in the extracellular matrix that gives integrity to surrounding hyaline cartilage. The therapy repairs damaged cartilage and restores functional and mechanical ability to withstand compressional, tensile, and shear forces.
- Primary indication
- in Autologous cultured chondrocytes are indicated the repair of symptomatic, single or multiple full-thickness cartilage defects of the knee with or without bone involvement in adults aged 55 years and less.Curator reviewed · 2 structured indications
- First approval
- United States, 1905 · European Union, 2020
- Brand names
Resolves to
What you can answer from here — as of April 23, 2025
Which other approved drugs treat the same conditions as Autologous cultured chondrocytes, and which companies have late-stage candidates in those indications?
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