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Darolutamide
go.drugbank.com/drugs/DB12941ApprovedInvestigationalDarolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). … The goal of treatment with darolutamide is to delay the progression of prostate cancer to metastatic disease, increasing quality of life and life expectancy for those with advanced prostate cancer.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesTerconazole
go.drugbank.com/drugs/DB00251Approved[A178093]Due to the existence of 2 stereocentres, there are 4 possible stereoisomers for terconazole. … Terconazole is an anti-fungal drug that is mainly used to treat vaginal yeast infections (or vaginal candidiasis). It is classified as a _triazole ketal derivative_.
Mixtures: TEREX-3, Terazol 3 Dual PakCategories: Heterocyclic Compounds, 1-RingMethylchloroisothiazolinone
go.drugbank.com/drugs/DB14197ApprovedSensitivity to Methylchloroisothiazolinone may be identified with a clinical patch test. … It is also a known dermatological sensitizer and allergen; some of its side effects include flaky or scaly skin, breakouts, redness or itchiness, and moderate to severe swelling in the eye area.
Categories: Heterocyclic Compounds, 1-Ring, Compounds used in a research, industrial, or household settingSynonyms: 4-Isothiazolin-3-one, 5-chloro-2-methyl-, 5-Chloro-2-methyl-3(2H)-isothiazoloneTrofinetide
go.drugbank.com/drugs/DB06045Approved[A258453] Trofinetide is marketed as DAYBUE and DAYBUE STIX in the United States, as DAYBUE in Canada, and as DAYBU in the European Union. … , making trofinetide the first and only treatment approved for Rett syndrome in the European Union.
Categories: MATE 1 Inhibitors, MATE 2 InhibitorsSynonyms: glycyl-L-2-methylprolyl-L-glutamic acidPropiverine
go.drugbank.com/drugs/DB12278ApprovedOveractive bladder (OAB) is a chronic condition of the lower urinary tract characterized by urinary urgency, increased frequency of urination, and nocturia (frequent waking during the night to urinate) … Propiverine is a widely used antimuscarinic drug with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB) [A32576].
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: MICTONORM SR 30MG SÜREKLI SALIMLI KAPSÜL, MICTONORM SR 45MG SÜREKLI SALIMLI KAPSÜLDornase alfa
go.drugbank.com/drugs/DB00003ApprovedInvestigationalThe 260-amino acid sequence of dornase alfa is identical to the endogenous human enzyme. … Dornase alfa cleaves extracellular DNA to 5´-phosphodinucleotide and 5´-phosphooligonucleotide end products without affecting intracellular DNA.
Synonyms: Deoxyribonuclease (human clone 18-1 protein moiety)Categories: Recombinant Human Deoxyribonuclease 1Ioxitalamic acid
go.drugbank.com/drugs/DB13444ApprovedWithdrawnUntil the last review in 2015, this drug is still available in the market.[L1113] … Ioxitalamate is an ionic iodinated contrast medium.[A27209] It is a first-generation contrast media formed by an ionic monomer with a high osmolarity of 1500-1800 mOsm/kg.
Categories: X-Ray Contrast Media, Iodinated, Compounds used in a research, industrial, or household settingSitagliptin
go.drugbank.com/drugs/DB01261ApprovedInvestigationalSitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256 … The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improve control of blood sugar[FDA label,A2255].
Mixtures: SITAGLIPTIN E METFORMINA GALENICUM, SITAGLIPTIN E METFORMINA GALENICUMCategories: Cytochrome P-450 Substrates, P-glycoprotein substratesAprocitentan
go.drugbank.com/drugs/DB15059ApprovedInvestigational[L50261] It was the first antihypertensive employing a novel mechanism to be approved in almost 40 years.[L50261] … Aprocitentan is a dual antagonist of endothelin receptors A and B used for treatment-resistant hypertension. It is the active metabolite of [macitentan].
Categories: P-glycoprotein substrates, Cytochrome P-450 CYP2C18 InhibitorsPatent Blue
go.drugbank.com/drugs/DB13967ApprovedInvestigational[L1113] The isomer isosulphan is used in the United States for the same indications than patent blue.[A32574] … Patent blue is aniline dye and it is one of the most common dyes used.[A32573] It is a sodium or calcium salt of diethylammonium hydroxide inner salt.
Salts: Patent Blue V calcium, Patent Blue V sodiumCategories: Compounds used in a research, industrial, or household setting