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Displaying results 3121 - 3130 of 10000 in total
  1. Drug

    Tezacaftor

    go.drugbank.com/drugs/DB11712
    ApprovedInvestigational

    [L1595] It was developed by Vertex Pharmaceuticals and FDA approved in combination with [ivacaftor] to manage cystic fibrosis.[L6814] This drug was approved by the FDA on February 12, 2018. … [A20298,A20299] As a result, CF patients produce thick, sticky mucus that clogs the ducts of organs where it is produced making patients more susceptible to complications such as infections, lung damage

    Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 Substrates
  2. Drug

    Z-Val-Ala-Asp fluoromethyl ketone

    go.drugbank.com/drugs/DB07744
    Experimental

    It does not require an esterase to hydrolyze the O-methyl ester like the cell-permeable form, Z-Val-Ala-Asp(O-Me) fluoromethyl ketone. … Non-methylated, competitive, and irreversible inhibitor of caspase 1, as well as other caspases,1 which can be used directly with purified enzymes.

  3. Drug

    Tannic acid

    go.drugbank.com/drugs/DB09372
    ApprovedInvestigational

    It acts as a weak acid. Tannic acid is found in the nutgalls formed by insects on twigs of certain oak trees (Quercus infectoria and other Quercus species). It is removed and used as medicine. … In the old days it was used as antidote against different poisons. Nowadays, tannic acid is applied topically for the treatment of cold sores, diaper rash, fever blisters and poison ivy.

  4. Drug

    Milbemycin oxime

    go.drugbank.com/drugs/DB11531
    ExperimentalVet approved

    Mixtures: Nexgard Spectra 150mg/30mg Chewable Tablets for Dogs >30-60kg, Nexgard Spectra 9mg/2mg Chewable Tablets for Dogs 2-3.5kg
  5. Drug

    CXA-10

    go.drugbank.com/drugs/DB15026
    Investigational

    CXA-10 is under investigation in clinical trial NCT03422510 (FIRSTx - A Study of Oral CXA-10 in Primary Focal Segmental Glomerulosclerosis (FSGS)).

    Synonyms: 10-nitro-9(E)-octadec-9-enoic acid
  6. Drug

    Sarecycline

    go.drugbank.com/drugs/DB12035
    ApprovedInvestigational

    Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007 … The acne often presents physically as a mixture of non-inflammatory and inflammatory lesions mainly on the face but on the back and chest as well [L4814].

  7. Drug

    Pivopril

    go.drugbank.com/drugs/DB19854
    Experimental

    The usage of the INN stem '-pril' in the name indicates that Pivopril is a angiotensin-converting enzyme inhibitor. Pivopril has a monoisotopic molecular weight of 329.17 Da.

  8. Drug

    Utibapril

    go.drugbank.com/drugs/DB20306
    Experimental

    The usage of the INN stem '-pril' in the name indicates that Utibapril is a angiotensin-converting enzyme inhibitor. Utibapril has a monoisotopic molecular weight of 449.2 Da.

  9. Drug

    Alacepril

    go.drugbank.com/drugs/DB21364
    Experimental

    The usage of the INN stem '-pril' in the name indicates that Alacepril is a angiotensin-converting enzyme inhibitor. Alacepril has a monoisotopic molecular weight of 406.16 Da.

  10. Drug

    Pentopril

    go.drugbank.com/drugs/DB21436
    Experimental

    The usage of the INN stem '-pril' in the name indicates that Pentopril is a angiotensin-converting enzyme inhibitor. Pentopril has a monoisotopic molecular weight of 333.16 Da.