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Polymenorrhoea
go.drugbank.com/conditions/DBCOND0019373Drugs: LynestrenolSynonyms: Excessive and frequent menstruation with regular cyclePafolacianine
go.drugbank.com/drugs/DB15413ApprovedInvestigational[A242572] On November 29, 2021, the FDA approved pafolacianine as an adjunct imaging agent for intraoperative identification of malignant lesions in adult patients with ovarian cancer. … [L39332] It is currently under investigation for use in FRα-positive pituitary adenoma, lung cancer,[A242577] and renal-cell carcinoma, which is thought to be the second-highest folate receptor-expressing
Categories: Compounds used in a research, industrial, or household settingNuclear factor NF-kappa-B complex
go.drugbank.com/bio_entities/BE0009554TargetHumansThe NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. … The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity
Synonyms: Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1Donanemab
go.drugbank.com/drugs/DB16647ApprovedInvestigational[A232214] On July 2, 2024, donanemab was approved by the FDA for the treatment of AD in patients with mild cognitive impairment or dementia symptoms. … [L50988] It works to reduce amyloid beta plaques and impede the progression of AD.[L50988]
Categories: Amino Acids, Peptides, and ProteinsRiltozinameran
go.drugbank.com/drugs/DB17095ApprovedInvestigational[L43922] It tends to cause less severe disease but is significantly more virulent than both the original virus and earlier variants (e.g. Delta). … [L43917] Riltozinameran is an mRNA vaccine encoding the S glycoprotein of SARS-CoV-2 Omicron variant lineage BA.1.
Vismodegib
go.drugbank.com/drugs/DB08828ApprovedInvestigationalVismodegib is an orally active small molecule that inhibits the hedgehog signaling pathway by binding to and inhibiting the transmembrane protein smoothened homologue (SMO). … In July 2013, it was approved by the EMA, and since then, it has been approved by several other countries.[A7370,A258618,L45803]
Categories: Antineoplastic and Immunomodulating AgentsSynonyms: 2-chloro-N-(4-chloro-3-pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide, Benzamide, 2-chloro-N-(4-chloro-3-(2-pyridinyl)phenyl)-4-(methylsulfonyl)-BAX 335
go.drugbank.com/drugs/DB17845InvestigationalBAX 335 is an adeno-associated virus vector 8 (AAV8)–based FIX gene therapy being investigated for the treatment of hemophilia B.[A259791]
Categories: Enzymes and Coenzymes, Amino Acids, Peptides, and ProteinsSynonyms: An Adeno-Associated Virus Serotype 8 (AAV8) Vector Expressing FIX Padua (AAV8.ss-3xCRM8-TTRFIX_R338Lopt)Technetium Tc-99m exametazime
go.drugbank.com/drugs/DB09163ApprovedIt can also be used for the labelling of leukocytes to localise intra-abdominal infections and inflammatory bowel disease. … Technetium Tc-99m exametazime is a radiopharmaceutical sold under the trade name Ceretec used in the detection of altered regional cerebral perfusion in stroke and other cerebrovascular diseases.
Categories: Indicators and Reagents, Compounds used in a research, industrial, or household settingPapain
go.drugbank.com/drugs/DB11193ApprovedWithdrawnPapain is also used as an ingredient in various enzymatic debriding preparations. … The enzyme is found to be localized in the skin of papaya, and is collected from slashed unripe papayas as a crude latex. Papain is used in food, pharmaceutical, textile, and cosmetic industries.
Mixtures: Bromelain and Papain Tab, NATURE'S BOUNTY NATUREL B-COMPLEX AND B-12 TABLET, 90 ADETCategories: Enzymes and CoenzymesSodium phosphate, dibasic
go.drugbank.com/drugs/DB14502ApprovedInvestigationalMixtures: Aminosyn II and Dextrose, Tis-U-Sol