Sodium phosphate, dibasic

Identification

Summary

Sodium phosphate, dibasic is an osmotic laxative used to cleanse the colon before a colonoscopy.

Brand Names
Bss Ophthalmic Solution, Fleet Mineral Oil, Glycerolyte 57, Isolyte S pH 7.4, K-phos Neutral, Osmoprep, Pedia-lax Liquid, Phoxillum, Tis-U-sol
Generic Name
Sodium phosphate, dibasic
DrugBank Accession Number
DB14502
Background

Not Available

Type
Small Molecule
Groups
Approved
Structure
Weight
Average: 141.9588
Monoisotopic: 141.940784382
Chemical Formula
HNa2O4P
Synonyms
  • Dibasic sodium phosphate anhydrous
  • Dibasic sodium phosphate, anhydrous
  • Disodium acid phosphate
  • Disodium hydrogen monophosphate
  • Disodium hydrogen phosphate
  • Disodium hydrogen phosphate, anhydrous
  • disodium hydrogenphosphate
  • Disodium phosphate
  • Phosphoric acid, disodium salt, anhydrous
  • Phosphoric acid, sodium salt (1:2)
  • Sodium phosphate dibasic
  • Sodium phosphate, dibasic
  • Sodium phosphate, dibasic (anhydrous)
  • Sodium phosphate, dibasic anhydrous
  • Sodium phosphate, dibasic, anhydrous
  • Sodium phosphate,dibasic,anhydrous
External IDs
  • E-339(II)
  • Fema no. 2398
  • INS NO.339(II)
  • INS-339(II)

Pharmacology

Indication

Used to treat constipation or to clean the bowel before a colonoscopy Label.

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Used in combination to treatConstipationCombination Product in combination with: Glycerin (DB09462), Sodium phosphate, monobasic (DB09449)••• ••••••••
Used in combination to treatHypophosphatemiaCombination Product in combination with: Monopotassium phosphate (DB09413), Sodium phosphate, monobasic (DB09449)••••••••••••••••••• ••••••
Used in combination to treatSevere constipationCombination Product in combination with: Sodium phosphate, monobasic (DB09449)••••••••••••••••••••
Associated Therapies
Contraindications & Blackbox Warnings
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Pharmacodynamics

Sodium phosphate inceases fecal water content to increase mobility through the large intestine 1.

Mechanism of action

Sodium phosphate is thought to work by increasing the amount of solute present in the intestinal lumen thereby creating an osmotic gradient which draws water into the lumen 1.

Absorption

Tmax for phosphate absorption with orally administered liquid sodium phosphate is 1-3h 3.

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Intamuscular LD50 of 250mg/kg and oral LD50 of 8290 mg/kg reported in rats 7. Phosphate toxicity is likely due to the disturbance of other electrolytes when phosphate levels are high, producing symptoms including tetany, dehydration, hypotension, tachycardia, hyperpyrexia, cardiac arrest and coma 4. Risk of raising phosphate levels through use of sodium phosphate appears to be higher in smaller patients 3.

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcetazolamideThe risk or severity of dehydration can be increased when Acetazolamide is combined with Sodium phosphate, dibasic.
AclidiniumThe therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Aclidinium.
AlfentanilThe therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Alfentanil.
AlloinThe risk or severity of adverse effects can be increased when Sodium phosphate, dibasic is combined with Alloin.
AlmasilateThe therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Almasilate.
Food Interactions
  • Take with a full glass of water.
  • Take with food.

Products

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Product Ingredients
IngredientUNIICASInChI Key
Sodium phosphate, dibasic dihydrate94255I6E2T10028-24-7KDQPSPMLNJTZAL-UHFFFAOYSA-L
Sodium phosphate, dibasic dodecahydrateE1W4N241FO10039-32-4DGLRDKLJZLEJCY-UHFFFAOYSA-L
Sodium phosphate, dibasic, heptahydrate70WT22SF4B7782-85-6PYLIXCKOHOHGKQ-UHFFFAOYSA-L
Sodium phosphate, dibasic, monohydrateBWZ7K44R51118830-14-1LVXHNCUCBXIIPE-UHFFFAOYSA-L
Active Moieties
NameKindUNIICASInChI Key
Sodium cationionicLYR4M0NH3717341-25-2FKNQFGJONOIPTF-UHFFFAOYSA-N
Phosphate ionionicNK08V8K8HR14265-44-2NBIIXXVUZAFLBC-UHFFFAOYSA-K
Product Images
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Aminoplasmal B. Braun 10%E Solution for Intravenous InfusionSodium phosphate, dibasic dodecahydrate (3.581 g/1000ml) + Alanine (10.5 g/1000ml) + Arginine (11.5 g/1000ml) + Aspartic acid (5.6 g/1000ml) + Glutamic acid (7.2 g/1000ml) + Glycine (12 g/1000ml) + Histidine (3 g/1000ml) + Isoleucine (5 g/1000ml) + Leucine (8.9 g/1000ml) + Lysine hydrochloride (8.56 g/1000ml) + Magnesium chloride hexahydrate (0.508 g/1000ml) + Methionine (4.4 g/1000ml) + Phenylalanine (4.7 g/1000ml) + Potassium acetate (2.453 g/1000ml) + Proline (5.5 g/1000ml) + Serine (2.3 g/1000ml) + Sodium acetate trihydrate (2.858 g/1000ml) + Sodium hydroxide (0.36 g/1000ml) + Threonine (4.2 g/1000ml) + Tryptophan (1.6 g/1000ml) + Tyrosine (0.4 g/1000ml) + Valine (6.2 g/1000ml)Injection, solutionIntravenousB.BRAUN MEDICAL INDUSTRIES SDN. BHD.2020-09-08Not applicableMalaysia flag
AMINOPLASMAL B.BRAUN 10% E SOLUTION FOR INFUSIONSodium phosphate, dibasic dodecahydrate (3.581 g/1000ml) + Alanine (10.50 g/1000ml) + Arginine (11.50 g/1000ml) + Aspartic acid (5.60 g/1000ml) + Glutamic acid (7.20 g/1000ml) + Glycine (12.00 g/1000ml) + Histidine (3.00 g/1000ml) + Isoleucine (5.00 g/1000ml) + Leucine (8.90 g/1000ml) + Lysine hydrochloride (8.56 g/1000ml) + Magnesium chloride hexahydrate (0.508 g/1000ml) + Methionine (4.40 g/1000ml) + Phenylalanine (4.70 g/1000ml) + Potassium acetate (2.453 g/1000ml) + Proline (5.50 g/1000ml) + Serine (2.30 g/1000ml) + Sodium acetate trihydrate (2.858 g/1000ml) + Sodium hydroxide (0.360 g/1000ml) + Threonine (4.20 g/1000ml) + Tryptophan (1.60 g/1000ml) + Tyrosine (0.40 g/1000ml) + Valine (6.20 g/1000ml)SolutionIntravenousB. BRAUN SINGAPORE PTE LTD2018-01-23Not applicableSingapore flag
AMINOPLASMAL® 10% ESodium phosphate, dibasic dodecahydrate (3.581 g) + Alanine (10.5 g) + Arginine (11.5 g) + Aspartic acid (5.6 g) + Glutamic acid (7.2 g) + Glycine (12 g) + Histidine (3 g) + Isoleucine (5 g) + Leucine (8.9 g) + Lysine hydrochloride (8.56 g) + Magnesium chloride hexahydrate (0.508 g) + Phenylalanine (4.7 g) + Potassium acetate (2.453 g) + Proline (5.5 g) + Racemethionine (4.4 g) + Serine (2.3 g) + Sodium acetate trihydrate (2.858 g) + Sodium hydroxide (0.36 g) + Threonine (4.2 g) + Tryptophan (1.6 g) + Tyrosine (0.4 g) + Valine (6.2 g)SolutionIntravenousB. BRAUN MEDICAL S.A.2015-07-27Not applicableColombia flag
Aminosyn II 7% M In 10% Dextrose(dual Chamber)Sodium phosphate, dibasic (49 mg / 100 mL) + Alanine (348 mg / 100 mL) + Arginine (356 mg / 100 mL) + Aspartic acid (245 mg / 100 mL) + Dextrose, unspecified form (5 g / 100 mL) + Glutamic acid (258 mg / 100 mL) + Glycine (175 mg / 100 mL) + Histidine (105 mg / 100 mL) + Isoleucine (231 mg / 100 mL) + Leucine (350 mg / 100 mL) + Lysine acetate (368 mg / 100 mL) + Magnesium chloride (30 mg / 100 mL) + Methionine (60 mg / 100 mL) + N-acetyltyrosine (94 mg / 100 mL) + Phenylalanine (104 mg / 100 mL) + Potassium chloride (97 mg / 100 mL) + Proline (252 mg / 100 mL) + Serine (186 mg / 100 mL) + Sodium chloride (120 mg / 100 mL) + Threonine (140 mg / 100 mL) + Tryptophan (70 mg / 100 mL) + Valine (175 mg / 100 mL)SolutionIntravenousHospira Healthcare Ulc1987-12-312012-08-03Canada flag
Aminosyn II 8.5% M In 20% Dextrose (dual Chamber)Sodium phosphate, dibasic (49 mg / 100 mL) + Alanine (422 mg / 100 mL) + Arginine (432 mg / 100 mL) + Aspartic acid (298 mg / 100 mL) + Dextrose, unspecified form (10 g / 100 mL) + Glutamic acid (314 mg / 100 mL) + Glycine (212 mg / 100 mL) + Histidine (128 mg / 100 mL) + Isoleucine (280 mg / 100 mL) + Leucine (425 mg / 100 mL) + Lysine acetate (446 mg / 100 mL) + Magnesium chloride (30 mg / 100 mL) + Methionine (73 mg / 100 mL) + N-acetyltyrosine (115 mg / 100 mL) + Phenylalanine (126 mg / 100 mL) + Potassium chloride (97 mg / 100 mL) + Proline (307 mg / 100 mL) + Serine (225 mg / 100 mL) + Sodium chloride (120 mg / 100 mL) + Threonine (170 mg / 100 mL) + Tryptophan (85 mg / 100 mL) + Valine (212 mg / 100 mL)SolutionIntravenousHospira Healthcare Ulc1987-12-312012-08-03Canada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
B.T.ENEMA 210 ML LAVMANSodium phosphate, dibasic (3.5 g/59ml) + Sodium phosphate, monobasic (9.5 g/59ml)EnemaRectalYENİŞEHİR LABORATUARI LTD. ŞTİ.2013-01-292022-04-11Turkey flag
B.T.ENEMA 67,5 ML LAVMANSodium phosphate, dibasic (3.5 g/59ml) + Sodium phosphate, monobasic (9.5 g/59ml)EnemaRectalYENİŞEHİR LABORATUARI LTD. ŞTİ.2013-01-292022-04-11Turkey flag
Dibasic Sodium Phosphate, Monobasic Potassium Phosphate and Monobasic Sodium PhosphateSodium phosphate, dibasic (852 mg/1) + Monopotassium phosphate (155 mg/1) + Sodium phosphate, monobasic, monohydrate (130 mg/1)TabletOralRising Pharmaceuticals, Inc.2012-06-28Not applicableUS flag
Dibasic Sodium Phosphate, Monobasic Potassium Phosphate and Monobasic Sodium PhosphateSodium phosphate, dibasic (852 mg/1) + Monopotassium phosphate (155 mg/1) + Sodium phosphate, monobasic, monohydrate (130 mg/1)TabletOralCardinal Health2012-06-282018-03-31US flag
Dibasic Sodium Phosphate, Monobasic Potassium Phosphate and Monobasic Sodium PhosphateSodium phosphate, dibasic (852 mg/1) + Monopotassium phosphate (155 mg/1) + Sodium phosphate, monobasic, monohydrate (130 mg/1)TabletOralAvera McKennan Hospital2015-03-112017-05-24US flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as alkali metal phosphates. These are inorganic compounds in which the largest oxoanion is phosphate, and in which the heaviest atom not in an oxoanion is an alkali metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Alkali metal oxoanionic compounds
Sub Class
Alkali metal phosphates
Direct Parent
Alkali metal phosphates
Alternative Parents
Inorganic sodium salts / Inorganic oxides
Substituents
Alkali metal phosphate / Inorganic oxide / Inorganic salt / Inorganic sodium salt
Molecular Framework
Not Available
External Descriptors
sodium phosphate (CHEBI:34683)
Affected organisms
Not Available

Chemical Identifiers

UNII
22ADO53M6F
CAS number
7558-79-4
InChI Key
BNIILDVGGAEEIG-UHFFFAOYSA-L
InChI
InChI=1S/2Na.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2*+1;/p-2
IUPAC Name
disodium hydrogen phosphate
SMILES
[Na+].[Na+].OP([O-])([O-])=O

References

General References
  1. Rex DK: Dosing considerations in the use of sodium phosphate bowel preparations for colonoscopy. Ann Pharmacother. 2007 Sep;41(9):1466-75. Epub 2007 Jul 24. [Article]
  2. Schanz S, Kruis W, Mickisch O, Kuppers B, Berg P, Frick B, Heiland G, Huppe D, Schenck B, Horstkotte H, Winkler A: Bowel Preparation for Colonoscopy with Sodium Phosphate Solution versus Polyethylene Glycol-Based Lavage: A Multicenter Trial. Diagn Ther Endosc. 2008;2008:713521. doi: 10.1155/2008/713521. [Article]
  3. Ehrenpreis ED: Increased serum phosphate levels and calcium fluxes are seen in smaller individuals after a single dose of sodium phosphate colon cleansing solution: a pharmacokinetic analysis. Aliment Pharmacol Ther. 2009 Jun 1;29(11):1202-11. doi: 10.1111/j.1365-2036.2009.03987.x. Epub 2009 Feb 27. [Article]
  4. Razzaque MS: Phosphate toxicity: new insights into an old problem. Clin Sci (Lond). 2011 Feb;120(3):91-7. doi: 10.1042/CS20100377. [Article]
  5. Biber J, Hernando N, Forster I: Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. doi: 10.1146/annurev-physiol-030212-183748. [Article]
  6. FDA Guide: Sodium Phosphate Tablet [Link]
  7. ChemIDPlus: Sodium Phosphate [Link]
KEGG Compound
C13558
ChemSpider
22625
ChEBI
34683
ChEMBL
CHEMBL1060

Clinical Trials

Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package
PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
4CompletedTreatmentColon Cleansing1somestatusstop reasonjust information to hide
4CompletedTreatmentObstructive Sleep Apnea (OSA) / Psoriasis1somestatusstop reasonjust information to hide
4RecruitingSupportive CareCataracts / Fuchs' Dystrophy1somestatusstop reasonjust information to hide
4RecruitingTreatmentColorectal Neoplasms / Surgery1somestatusstop reasonjust information to hide
4Unknown StatusTreatmentCritical Care1somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SolutionIntravenous10.50 g/1000ml
SolutionIntravenous
Injection, solutionIntravenous
Powder, for solutionIntraocular
SolutionHemodialysis; Intravenous
SolutionHemodialysis; Intravenous0.187 g/L
Kit; solutionIntraocular
Solution, concentrateRectal
SolutionRectal
LiquidOral
KitIntravenous
SolutionUnknown
Tablet, coatedOral
SolutionOral
LiquidBuccal
SprayBuccal
Kit; solutionIntraocular; Irrigation
LiquidTopical
Tablet, effervescentOral
EmulsionIntravenous
EmulsionParenteral
TabletOral
SolutionOral1.2 g/5ml
SolutionHemodialysis
InjectionIntravenous
EnemaRectal
SolutionRespiratory (inhalation)
Injection, solution, concentrateIntravenous
PowderOral
SolutionOral0.9 g/5ml
IrrigantIrrigation
SolutionIrrigation
LiquidIrrigation
Syrup
Solution
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)Region
US7687075No2010-03-302028-06-22US flag

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-1Chemaxon
pKa (Strongest Acidic)1.8Chemaxon
Physiological Charge-2Chemaxon
Hydrogen Acceptor Count4Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area83.42 Å2Chemaxon
Rotatable Bond Count0Chemaxon
Refractivity12.41 m3·mol-1Chemaxon
Polarizability5.24 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-106.69356
predicted
DeepCCS 1.0 (2019)
[M+H]+109.840004
predicted
DeepCCS 1.0 (2019)
[M+Na]+118.66112
predicted
DeepCCS 1.0 (2019)

Transporters

Kind
Protein
Organism
Humans
Pharmacological action
No
General Function
Not Available
Specific Function
Not Available
Gene Name
SLC20A1
Uniprot ID
Q8WUM9
Uniprot Name
Sodium-dependent phosphate transporter 1
Molecular Weight
73699.01 Da
References
  1. Biber J, Hernando N, Forster I: Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. doi: 10.1146/annurev-physiol-030212-183748. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
No
General Function
Virus receptor activity
Specific Function
Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular m...
Gene Name
SLC20A2
Uniprot ID
Q08357
Uniprot Name
Sodium-dependent phosphate transporter 2
Molecular Weight
70391.755 Da
References
  1. Biber J, Hernando N, Forster I: Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. doi: 10.1146/annurev-physiol-030212-183748. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
No
General Function
Sodium:phosphate symporter activity
Specific Function
Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx.
Gene Name
SLC34A1
Uniprot ID
Q06495
Uniprot Name
Sodium-dependent phosphate transport protein 2A
Molecular Weight
68936.53 Da
References
  1. Biber J, Hernando N, Forster I: Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. doi: 10.1146/annurev-physiol-030212-183748. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
No
General Function
Sodium:phosphate symporter activity
Specific Function
May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the s...
Gene Name
SLC34A2
Uniprot ID
O95436
Uniprot Name
Sodium-dependent phosphate transport protein 2B
Molecular Weight
75758.535 Da
References
  1. Biber J, Hernando N, Forster I: Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. doi: 10.1146/annurev-physiol-030212-183748. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
No
General Function
Sodium:phosphate symporter activity
Specific Function
May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 20-30% of the apical influx.
Gene Name
SLC34A3
Uniprot ID
Q8N130
Uniprot Name
Sodium-dependent phosphate transport protein 2C
Molecular Weight
63548.94 Da
References
  1. Kirchheiner J, Meineke I, Muller G, Roots I, Brockmoller J: Contributions of CYP2D6, CYP2C9 and CYP2C19 to the biotransformation of E- and Z-doxepin in healthy volunteers. Pharmacogenetics. 2002 Oct;12(7):571-80. [Article]

Drug created at July 11, 2018 17:31 / Updated at January 08, 2021 01:07