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Desoximetasone
go.drugbank.com/drugs/DB00547ApprovedA topical anti-inflammatory glucocorticoid used in dermatoses, skin allergies, psoriasis, etc.
Mixtures: R-DIM®, Desoximetasone 0.05% / Niacinamide 4%Synonyms: 9alpha-fluoro-16alpha-methyl-delta(1)-corticosterone, (11β,16α)-9-fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dioneBrentuximab
go.drugbank.com/drugs/DB05471InvestigationalWe are collaborating with the National Cancer Institute (NCI) on three clinical trials of SGN-30 in combination with chemotherapy for the treatment of relapsed Hodgkin lymphoma, front-line ALCL and pediatric … SGN-30 has demonstrated objective antitumor responses as a single agent in phase II clinical trials.
Asciminib
go.drugbank.com/drugs/DB12597ApprovedInvestigationalMore specifically, it is an inhibitor of the ABL1 kinase activity of the BCR-ABL1 fusion protein[L38995] which serves as a driver of CML proliferation in most patients with the disease. … Asciminib is a tyrosine kinase inhibitor (TKI) used in the treatment of chronic-phase Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML).
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesTemazepam
go.drugbank.com/drugs/DB00231ApprovedIn particular, before temazepam saw regular prescription use in civilians it was - and still is - employed by the US military as a sedative-hypnotic medication to be taken by soldiers, pilots, etc. to … capable of developing drug tolerance, physical dependence, and addiction in users.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 SubstratesProducts: Co Temazepam Capsules 15mg, Co Temazepam Capsules 30mgGrazoprevir
go.drugbank.com/drugs/DB11575ApprovedIn a joint recommendation published in 2016, the American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) recommend Grazoprevir as first line therapy … in combination with [DB11574] for genotypes 1a, 1b, and 4 of Hepatitis C [A19593].
Mixtures: ZEPATIER® TABLETAS RECUBIERTASCategories: Antivirals for treatment of HCV infections, P-glycoprotein substratesDesonide
go.drugbank.com/drugs/DB01260ApprovedInvestigationalA nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses.
Synonyms: 11β,21-dihydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dioneMixtures: SPORUM-D, APOLAR NCeftobiprole
go.drugbank.com/drugs/DB04918ApprovedWithdrawnThe EMA's Committee for Medicinal Products for Human Use (CHMP) adopted a negative opinion of ceftobiprole medocaril in February 2010, recommending the refusal of its marketing authorization in the European … Union primarily due to data quality issues in pivotal clinical studies.
Categories: Heterocyclic Compounds, 2-RingMipomersen
go.drugbank.com/drugs/DB05528ApprovedMipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. … It is marketed under the brand name Kynamro in the United States, and the FDA label includes a black box warning of hepatoxicity.
Categories: Compounds used in a research, industrial, or household setting, Apolipoprotein B-100 Synthesis InhibitorRamoplanin
go.drugbank.com/drugs/DB04952ExperimentalRamoplanin is a novel glycolipodepsipeptide antibiotic under development for the treatment of CDAD.
Muparfostat
go.drugbank.com/drugs/DB05808InvestigationalMuparfostat (PI-88) is a mixture of highly sulfated, monophosphorylated mannose oligosaccharides, derived from the extracellular phosphomannan of the yeast Pichia (Hansenula) holstii, with potential antiangiogenic
Synonyms: -D-MANNAN, (1->3)-, 6-(DIHYDROGEN PHOSPHATE) TRIS(HYDROGEN SULFATE), Heparanase inhibitor PI-88