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Displaying results 311 - 320 of 10000 in total
  1. Drug

    Uridine triacetate

    go.drugbank.com/drugs/DB09144
    Approved

    It reduces toxicity and cell-death associated with two cytotoxic intermediates: 5-fluoro-2'-deoxyuridine-5'-monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). … It is provided in the prodrug form as uridine triacetate as this form delivers 4- to 6-fold more uridine into the systemic circulation compared to equimolar doses of uridine itself.

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 2',3',5'-tri-O-acetyluridine, 2',3',5'-Triacetyluridine
  2. Drug

    Cephalexin

    go.drugbank.com/drugs/DB00567
    ApprovedInvestigationalVet approved

    [A179071] Cephalexin is used to treat a number of susceptible bacterial infections through inhibition of cell wall synthesis.[A179083,L6547] Cephalexin was approved by the FDA on 4 January 1971. … [A179071,A179074] This antibiotic contains a beta lactam and a dihydrothiazide.

    Synonyms: 7-beta-(D-alpha-Amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acid, (6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acidInternational brands: L-Keflex
  3. Drug

    Histamine

    go.drugbank.com/drugs/DB05381
    ApprovedInvestigational

    It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. … A depressor amine derived by enzymatic decarboxylation of histidine.

    Mixtures: Histamine DHCl 0.10 Percent and Menthol 2 Percent, Md Science CannabidiolCategories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP3A Inhibitors
  4. Drug

    Estramustine

    go.drugbank.com/drugs/DB01196
    ApprovedWithdrawn

    A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.

    Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsSynonyms: Estradiol 3-(N,N-bis(2-chloroethyl)carbamate), 17β-Estradiol 3-(bis(2-chloroethyl)carbamate)
  5. Drug

    Dasabuvir

    go.drugbank.com/drugs/DB09183
    Approved

    Dasabuvir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). … HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, and affecting 72% of all chronic HCV patients [L852].

    Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: Sodium 3-(3-tert-butyl-4-methoxy-5-{6­ [(methylsulfonyl)amino]naphthalene-2-yl}phenyl)-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-ide hydrate (1:1:1), N-{6-[3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl]naphthalen-2-yl}methanesulfonamide
  6. Drug

    Doxapram

    go.drugbank.com/drugs/DB00561
    ApprovedInvestigationalVet approved

    A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone
  7. Drug

    Ezogabine

    go.drugbank.com/drugs/DB04953
    ApprovedWithdrawn

    It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures … Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine.

    Synonyms: ethyl {2-amino-4-[(4-fluorobenzyl)amino]phenyl}carbamate, N-(2-Amino-4-(4-fluorobenzylamino)-phenyl) carbamic acid ethyl ester
  8. Drug

    4-[(3R)-3-{[2-(4-FLUOROPHENYL)-2-OXOETHYL]AMINO}BUTYL]BENZAMIDE

    go.drugbank.com/drugs/DB08672
    Experimental

    Synonyms: 4-[(3R)-3-{[2-(4-FLUOROPHENYL)-2-OXOETHYL]AMINO}BUTYL]BENZAMIDE
  9. Drug

    Cinnamaldehyde

    go.drugbank.com/drugs/DB14184
    Approved

    Sensitivity to cinnamaldehyde may be identified with a clinical patch test. … Cinnamaldehyde is a naturally occurring flavonoid that gives the spice cinnamon its flavour and odour.

    Synonyms: (E)-3-Phenyl-2-propenal, (3E)-3-phenylprop-2-enalCategories: Compounds used in a research, industrial, or household setting
  10. Drug

    Benzoylpas

    go.drugbank.com/drugs/DB19382
    ApprovedWithdrawn

    Synonyms: Benzoic acid, 4-(benzoylamino)-2-hydroxy-, 4-benzamidosalicylate