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Displaying results 3201 - 3210 of 10000 in total
  1. Target

    Retinol dehydrogenase 16

    go.drugbank.com/bio_entities/BE0011917
    EnzymeHumans

    Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes (PubMed:10329026, PubMed:12534290, PubMed:9677409). … Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction (PubMed:10329026, PubMed:29541409, PubMed:9677409)

    Polypeptides: Retinol dehydrogenase 16
  2. Drug

    MK-1064

    go.drugbank.com/drugs/DB15028
    Investigational

    MK-1064 is under investigation in clinical trial NCT02549014 (A Single Dose Study of the Safety, Pharmacokinetics and Pharmacodynamics of MK-1064 (MK-1064-001)).

  3. Drug

    MK-6325

    go.drugbank.com/drugs/DB15249
    Investigational

    MK-6325 is under investigation in clinical trial NCT01329913 (Safety, Pharmacokinetics, and Pharmacodynamics of MK-6325 in Hepatitis C Virus (HCV) Infections (MK-6325-003)).

  4. Drug

    Prasterone

    go.drugbank.com/drugs/DB01708
    ApprovedInvestigationalNutraceutical

    In Canada, a prescription is required to buy DHEA. … In November 2016, DHEA was approved (as Intrarosa) to treat women experiencing moderate to severe pain during sexual intercourse (dyspareunia), a symptom of vulvar and vaginal atrophy (VVA), due to menopause

    Synonyms: 3β-hydroxyandrost-5-en-17-one, 3-beta-hydroxy-5-androsten-17-oneCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inhibitors
  5. Drug

    Opicapone

    go.drugbank.com/drugs/DB11632
    ApprovedInvestigational

    [A36938, A203048] Many patients with Parkinson’s disease treated with levodopa plus a dopa decarboxylase (DDC) inhibitor (eg carbidopa) experience motor complications over time, which calls for the management … Exhibiting a long duration of action that exceeds 24 hours, opicapone can be administered once-daily [L2336] and demonstrates the lowest risk for cytotoxicity compared to other catechol-O-methyltransferase

    Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP2B6 Inhibitors
  6. Drug

    Paromomycin

    go.drugbank.com/drugs/DB01421
    ApprovedInvestigational

    An oligosaccharide antibiotic produced by various streptomyces. [PubChem]

    Synonyms: (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranosideProducts: GABROSIDIN 0.5 G ENJEKTABL FLAKON, 1 ADET
  7. Indication

    BCG-unresponsive non-muscle invasive bladder cancer

    go.drugbank.com/conditions/DBCOND0153568
    Drugs: Inbakicept · Nogapendekin alfa
    Synonyms: Non-muscle invasive bladder cancer ("nmibc") unresponsive/intolerant to bcg
  8. Drug

    Oteracil

    go.drugbank.com/drugs/DB03209
    ApprovedInvestigational

    By mimicking a class of compounds called "pyrimidines" that are essential components of RNA and DNA, 5-FU is able to insert itself into strands of DNA and RNA, thereby halting the replication process necessary … Oteracil is an adjunct to antineoplastic therapy, used to reduce the toxic side effects associated with chemotherapy.

    Synonyms: 5-azaorotic acidMixtures: TS-ONE CAPSULE 20, TS-ONE CAPSULE 20
  9. Drug

    Eflornithine

    go.drugbank.com/drugs/DB06243
    ApprovedInvestigationalWithdrawn

    [A262823,L49318] Subsequently, on December 14, 2023, the FDA approved eflornithine again but under the brand name IWILFIN as an oral maintenance therapy to reduce the risk of relapse in adult and pediatric … [A262839] In 1960 and 2000, the FDA approved eflornithine under the brand names ORNIDYL and VANIQUA for the treatment of African trypanosomiasis and hirsutism, respectively, but has since been discontinued

    Products: EFLORİN %13.9 KREM, 60 GRAM, EFLORİN %13.9 KREM, 30 GRAM
  10. Drug

    Nipocalimab

    go.drugbank.com/drugs/DB16257
    ApprovedInvestigational

    Nipocalimab-aahu is a neonatal Fc receptor (FcRn) blocker used to treat certain antibody-mediated autoimmune diseases. … [L64042] It is an aglycosylated, fully human IgG1 monoclonal antibody that binds FcRn and blocks the receptor's recycling of immunoglobulin G (IgG), thereby lowering circulating IgG levels, including pathogenic