Paromomycin

DB01421ApprovedInvestigationalSmall moleculeAntiprotozoals

Paromomycin is an aminoglycoside antibiotic used in the treatment of acute and chronic intestinal amebiasis, and as an adjunct for the management of hepatic coma. An oligosaccharide antibiotic produced by various streptomyces.

Mechanism: Paromomycin inhibits protein synthesis by binding to 16S ribosomal RNA. Bacterial proteins are synthesized by ribosomal RNA complexes which are composed of 2 subunits, a large subunit (50s) and small (30s) subunit, which forms a 70s ribosomal subunit. tRNA binds to the top of this ribosomal structure. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced. Continuous production of defective proteins eventually leads to bacterial death.
Curator reviewed
Primary indication: For the treatment of acute and chronic intestinal amebiasis (it is not effective in extraintestinal amebiasis).Curator reviewed · 4 structured indications
Formula / weight: C₂₃H₄₅N₅O₁₄ · 615.6285 g/mol (avg)
First approval: Canada, 2022 · United States, 1981
Also known as: Aminosidin · Aminosidine · Catenulin · Crestomycin · Estomycin
Code names: ANTIBIOTIC 503-3 · ANTIBIOTIC SF 767B · R-400
Brand names: Humatin

Resolves to

Compound

UNII61JJC8N5ZKCAS7542-37-2ChEMBLCHEMBL370143ChEBI7934PubChem165580KEGGC00832

Clinical / RWD

RxNorm7934ATCA07AA06PharmGKBPA164784023

Structure

InChIKeyUOZODPSAJZTQNH-LSWIJEOBSA-NSMILES

NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O

Targets

Q5SHN7rpsJP08865RPSAQ96L21RPL10L

What you can answer from here — as of September 12, 2026

4Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

876Drug interactionsStructured to mechanism, not free text

22Clinical trialsPhase, status and sponsor resolved per trial

4Structured indicationsCondition, population, route and combination as fields, not prose

1ContraindicationEach with its own population and attribute set

27Marketed productsAcross 6 countries and 16 labellers

1ATC codeIncluding every combination product, plus 13 drug categories

6+ReferencesStructured and connected to the statements they support

Which drugs share a target with Paromomycin, and which of those have an active Phase 3 trial?

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