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Dabrafenib
go.drugbank.com/drugs/DB08912ApprovedInvestigational[L41955] In May 2018, Tafinlar (dabrafenib), in combination with Mekinist ([DB08911]), was approved to treat anaplastic thyroid cancer caused by an abnormal BRAF V600E gene.[L41955] … Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway.
Categories: Antineoplastic and Immunomodulating AgentsProducts: TAFINLAR HARD CAPSULE 50MG, TAFINLAR HARD CAPSULE 75MGMibefradil
go.drugbank.com/drugs/DB01388ApprovedWithdrawnMibefradil was withdrawn from the market in 1998 because of potentially harmful interactions with other drugs.
Categories: Calcium-Regulating Hormones and Agents, Metabolic Side Effects of Drugs and SubstancesN-Acetylglucosamine
go.drugbank.com/drugs/DB00141ApprovedInvestigationalNutraceuticalThe N-acetyl derivative of glucosamine.
ISS-1018
go.drugbank.com/drugs/DB05463InvestigationalISS 1018 signals through Toll-like receptor 9 (TLR9) to induce the production of immunoglobulin by B cells and interferon (IFN) -alpha, IFN-beta, interleukin-12 (IL-12), and tumor necrosis factor - alpha … ISS 1018 CpG ODN promotes antigen presentation and co-stimulatory molecule expression.
Categories: Nucleic Acids, Nucleotides, and NucleosidesDitiocarb zinc
go.drugbank.com/drugs/DB14193ApprovedDitiocarb zinc, also known as Diethyldithiocarbamic acid zinc salt, is a known chelator for copper and zinc. It also a dermatological sensitizer and allergen.
Categories: Agents for Treatment of Hemorrhoids and Anal Fissures for Topical UseN-alkyl ethylbenzyl dimethyl ammonium (C12-C14)
go.drugbank.com/drugs/DB11202ApprovedEmployed in a great variety of cleaning agents and sanitizing agents, it possesses relatively broad gram-positive and gram-negative antibacterial activities and relatively little chance for systemic absorption … It is found in sanitizing solutions or soaps as an active ingredient due to its antimicrobial properties.
Mixtures: Prevent X Hand Sanitizer and Antiseptic Skin Protectant, Antimicrobial Hand CleanerBismuth subcitrate potassium
go.drugbank.com/drugs/DB09275ApprovedInvestigationalA bismuth compound used for peptic ulcer and gastro-oesophageal reflux disease (GORD).
Mixtures: Bismuth Subcitrate Potassium, Metronidazole and Tetracycline Hydrochloride, Bismuth Subcitrate Potassium, Metronidazole, and Tetracycline HydrochlorideCategories: Alimentary Tract and Metabolism, Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord)Keyhole limpet hemocyanin
go.drugbank.com/drugs/DB05299ApprovedInvestigationalWithdrawnKeyhole limpet hemocyanin is an immune modulator, given as a vaccine to help the body respond to cancer. A natural protein isolated from the marine mollusc keyhole limpet. … Keyhole limpet hemocyanin is an immunogenic carrier protein that, in vivo, increases antigenic immune responses to haptens and other weak antigens such as idiotype proteins.
Categories: Amino Acids, Peptides, and ProteinsTemafloxacin
go.drugbank.com/drugs/DB01405ApprovedWithdrawnIt was first approved for use in the U.S. market in 1992, but was withdrawn shortly due to the reports of serious adverse reactions, such as allergic reactions and hemolyric anemia, resulting in three … Temafloxacin is an antibiotic agent belonging to the fluoroquinolone drug class.
Sipavibart
go.drugbank.com/drugs/DB21908ApprovedInvestigational[A274098] It works by binding to the SARS-CoV-2 spike protein receptor binding domain (RBD), neutralize the virus and preventing its entry into the host cell. … [A274088] It was later approved in Europe in January 2025 and in Canada in March 2025.
Categories: Amino Acids, Peptides, and Proteins, Immune Sera and Immunoglobulins