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Tolebrutinib
go.drugbank.com/drugs/DB18715InvestigationalSynonyms: 2h-imidazo(4,5-c)pyridin-2-one, 4-amino-1,3-dihydro-1-((3r)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl)-3-(4-phenoxyphenyl)-, 4-amino-1,3-dihydro-1-((3r)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl)-3-(4-phenoxyphenyl)-2h-imidazo(4,5-c)pyridin-2-oneAGI-134
go.drugbank.com/drugs/DB19005InvestigationalAGI-134 is under investigation in clinical trial NCT03593226 (Study to Evaluate Safety & Tolerability of AGI-134 in Solid Tumour).
Synonyms: 2R)-1-((2-(5-((3-(((2R,3R,4R,5S,6R)-5-(((2S,3R,4S,5S,6R)-3,5-DIHYDROXY-6-(HYDROXYMETHYL)-4-(((2R,3R,4S,5R,6R)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)OXAN-2-YL)OXY)OXAN-2-YL)OXY)-3-ACETAMIDO-4-HYDROXY-6-(HYDROXYMETHYL, )OXAN-2-YL)OXY)PROPYL)CARBAMOYL) PENTANAMICotsiranib
go.drugbank.com/drugs/DB18404InvestigationalSynonyms: STP705 (small interfering RNA (siRNA) therapeutic directed against transforming growth factor-beta 1 (TGF-beta 1) and cyclo-oxygenase-2 (COX-2))Befiradol
go.drugbank.com/drugs/DB19033InvestigationalBefiradol is under investigation in clinical trial NCT05148884 (Study to Assess the Safety, Tolerability and Preliminary Efficacy of NLX-112 Versus Placebo in L-dopa-induced Dyskinesia).
Categories: Heterocyclic Compounds, 1-Ring, Serotonin 5-HT1 Receptor AgonistsSynonyms: (2E)-2-butenedioate, (3-chloro-4-fluorophenyl)(4-fluoro-4-((((5-methylpyridin-2-yl)methyl)amino)methyl)piperidin-1-yl)methanoneNGD-4715
go.drugbank.com/drugs/DB06027ExperimentalNGD-4715 functions as a melanin-concentrating hormone receptor 1 antagonist.
Synonyms: 1-(5-bromo-6-methoxypyridin-2-yl)-4-(3,4-dimethoxybenzyl)piperazine, 1-(5-bromo-6-methoxypyridin-2-yl)-4-[(3,4-dimethoxyphenyl)methyl]piperazine1-Naphthyl-L-alanine
go.drugbank.com/drugs/DB07365ExperimentalSynonyms: Naphthalen-2-yl-3-alanine, (S)-2-Amino-3-(naphthalen-1-yl)propanoic acidL-cysteic acid
go.drugbank.com/drugs/DB03661ExperimentalL-cysteic acid is a beta-sulfoalanine. It is an amino acid with a C-terminal sulfonic acid group which has been isolated from human hair oxidized with permanganate.
Synonyms: (2R)-2-amino-3-sulfopropanoic acid, 2-Amino-3-sulfopropionic acidNP-51
go.drugbank.com/drugs/DB16995InvestigationalSynonyms: (+/-)-o-(3-piperidino-2-hydroxy-1-propyl)nicotinic acid amidoxime, 3-pyridinecarboximidamide, n-(2-hydroxy-3-(1-piperidinyl)propoxy)-Categories: Heterocyclic Compounds, 1-Ring(4aS,6R,8aS)-11-[8-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)octyl]-6-hydroxy-3-methoxy-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
go.drugbank.com/drugs/DB02673ExperimentalSynonyms: (4aS,6R,8aS)-11-[8-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)octyl]-6-hydroxy-3-methoxy-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-iumTigozertinib
go.drugbank.com/drugs/DB19239InvestigationalTigozertinib (BLU-945) is currently under investigation in clinical trial NCT04862780 (Phase 1/2 Study Targeting EGFR Resistance Mechanisms in NSCLC) for the treatment of NSCLC.
Synonyms: N-{2-[(3S,4R)-3-fluoro-4-methoxypiperidin-1-yl]pyrimidin-4-yl}-5-(propan-2-yl)-8-[(2R,3S)-2-methyl-3-[(methanesulfonyl)methyl]azetidin-1-yl]isoquinolin-3-amine, 3-ISOQUINOLINAMINE, N-(2-((3S,4R)-3-FLUORO-4-METHOXY-1-PIPERIDINYL)-4-PYRIMIDINYL)-5-(1-METHYLETHYL)-8-((2R,3S)-2-METHYL-3-((METHYLSULFONYL)METHYL)-1-AZETIDINYL)-