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Soblidotin
go.drugbank.com/drugs/DB12677InvestigationalSoblidotin has been used in trials studying the treatment of Sarcoma, Lung Cancer, and Unspecified Adult Solid Tumor, Protocol Specific.
WP-1066
go.drugbank.com/drugs/DB12679InvestigationalWP1066 has been used in trials studying the treatment of Melanoma, Brain Cancer, Solid Tumors, and Central Nervous System Neoplasms.
Synonyms: (E)-3-(6-Bromo-pyridin-2-yl)-2-cyano-N-((S)-1-phenyl-ethyl)-acryl amide, 2-PROPENAMIDE, 3-(6-BROMO-2-PYRIDINYL)-2-CYANO-N-((1S)-1-PHENYLETHYL)-, (2E)-Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingErteberel
go.drugbank.com/drugs/DB07933InvestigationalErteberel is an estrogen receptor beta agonist that has been used in trials studying the treatment of Benign Prostatic Hyperplasia.
Synonyms: (3aS,4R,9bR)-4-(4-Hydroxyphenyl)-1,2,3,3a,4,9b-hexahydrocyclopenta(c)(1) benzopyran-8-olCategories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingAmylmetacresol
go.drugbank.com/drugs/DB13908ApprovedThe acute sore throat (pharyngitis) is one of the most common conditions for which children are seen in the primary care setting. … Amylmetacresol is an antiseptic available in Canada over-the-counter in a number of lozenges for the treatment of sore throat and minor mouth infections [L2570], [L2571].
Synonyms: 6-n-amyl-m-cresol, 6-n-pentyl-m-cresolMixtures: ซีพาคอล(R) อาร์เอ็กซ์, ซีพาคอล(R) อาร์เอ็กซ์Pork collagen
go.drugbank.com/drugs/DB14100ApprovedIt has been used since 1995 as Carticel and gained biologic license in 1997. The surgical implantation was first performed in Sweden. … The surgical implantation shows a tolerable safety profile and efficacy up to 4 years, but it is not indicated for patients with osteoarthritis.
Tandutinib
go.drugbank.com/drugs/DB05465InvestigationalApproximately 25 to 30 percent of all adult AML patients have a mutation of the FLT3 gene. The use of MLN518 to treat AML has been granted fast-track status by the U.S. Food and Drug Administration. … MLN518 is a novel, oral, small molecule designed to inhibit type III receptor tyrosine kinases, including FLT3, (platelet-derived growth-factor receptor) PDGFR and c-KIT.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingZucapsaicin
go.drugbank.com/drugs/DB09120ApprovedWithdrawnIt is a modulator of transient receptor potential cation channel subfamily V member 1 (TRPV-1), also known as the vanilloid or capsaicin receptor 1, that reduces pain and improves articular functions. … Zucapsaicin has also been evaluated for the management of several conditions manifested by chronic nerve pain.
Synonyms: (Z)-CapsaicinCategories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP2C19 InhibitorsZileuton
go.drugbank.com/drugs/DB00744ApprovedWithdrawnBoth the R(+) and S(-) enantiomers are pharmacologically active as 5-lipoxygenase inhibitors in in vitro systems. The immediate release tablet of Zileuton has been withdrawn from the US market. … Zileuton relieves such symptoms through its selective inhibition of 5-lipoxygenase, the enzyme that catalyzes the formation of leukotrienes from arachidonic acid.
Synonyms: (±)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea, N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyureaCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsAcoramidis
go.drugbank.com/drugs/DB17999ApprovedInvestigational[A264768] Acoramidis has been in development since at least 2013. … [A264768] Although they share a mechanism of action, acoramidis is more selective for TTR and is a more potent stabilizer when compared to tafamidis.
Synonyms: 3-(3-(3,5-dimethyl-1h-pyrazol-4-yl)propoxy)-4-fluorobenzoic acidCategories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP2C9 InhibitorsMalic acid
go.drugbank.com/drugs/DB12751InvestigationalMalic acid has been used in trials studying the treatment of Xerostomia, Depression, and Hypertension.
Mixtures: AMINOPLASMAL-5% E INFUSION, Aminoven Infant 10% w/v