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Displaying results 3371 - 3380 of 8974 in total
  1. Drug

    Catridecacog

    go.drugbank.com/drugs/DB09310
    Approved

    For people with congenital deficiency or mutation of Factor XIII, a rare bleeding disorder, exogenous replacement of this key coagulation factor is essential for management and prevention of bleeding episodes … Other drug products with similar structure and function to Coagulation Factor XIII A-Subunit (Recombinant) include [DB12909], which is a purified endogenous (human) form of coagulation factor XIII.

  2. Drug

    Inotersen

    go.drugbank.com/drugs/DB14713
    ApprovedInvestigational

    Inotersen is a transthyretin-directed antisense oligonucleotide for the treatment of the polyneuropathy caused by hereditary transthyretin-mediated amyloidosis in adults. … Hereditary transthyretin amyloidosis is caused by single-nucleotide variants in the gene encoding transthyretin (TTR), which lead to transthyretin misfolding and the deposition of amyloid substance systemically

  3. Drug

    Bafilomycin A1

    go.drugbank.com/drugs/DB06733
    Experimental

    The bafilomycins refer to a category of toxic macrolide antibiotics that are derivatives of Streptomyces griseus. … These compounds all appear in the same fermentation and have similar biological activity. Bafilomycins are specific inhibitors of vacuolar-type H+-ATPase. (V-ATPase).

  4. Drug

    Manidipine

    go.drugbank.com/drugs/DB09238
    ApprovedInvestigationalWithdrawn

    It is selective for vasculature and does not produce effects on the heart at clinically relevant dosages.

  5. Drug

    Ensifentrine

    go.drugbank.com/drugs/DB16157
    ApprovedInvestigational

    [L50903] On June 26, 2024, the FDA announced the approval of an inhaled product of ensifentrine for the treatment of chronic obstructive pulmonary disease (COPD) in adults, which allows the drug to be … directly delivered to the lungs.

  6. Drug

    Moricizine

    go.drugbank.com/drugs/DB00680
    ApprovedWithdrawn

    An antiarrhythmia agent used primarily for ventricular rhythm disturbances.

  7. Drug

    Ubiquinol

    go.drugbank.com/drugs/DB11340
    ApprovedInvestigational

    Ubiquinol (CoQH2) is a reduced form of coenzyme Q10 (CoQ10) that acts as an active antioxidant that prevents the initiation and propagation of lipid peroxidation in biological membranes and human low-density … It plays an essential role in maintaining cellular defense against oxidative damage and also sustains the effects of vitamin E by regenerating the vitamin from the tocopheroxyl radical, but ubiquinol is

    Mixtures: Co-Balamin, Co-Veratrol
  8. Drug

    Quinupristin

    go.drugbank.com/drugs/DB01369
    Approved

    Quinupristin/dalfopristin is a combination of two antibiotics used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. … The combination of the two components acts synergistically and is more effective in vitro than each component alone.

  9. Drug

    Crotalus scutulatus antivenin

    go.drugbank.com/drugs/DB13891
    Approved

    It is intravenously administered to limit systemic toxicity [FDA label], [L2857], [L2858]. … CroFab is more specifically tailored for crotalids of North America and is less allergenic than whole immunoglobulin antivenoms [L2861].

  10. Drug

    Tamsulosin

    go.drugbank.com/drugs/DB00706
    ApprovedInvestigational

    [Label] Antagonism of these receptors leads to relaxation of smooth muscle in the prostate and detrusor muscles in the bladder, allowing for better urinary flow. … [Label] It is indicated for the treatment of signs and symptoms of benign prostatic hypertrophy.

    Mixtures: Duoride-T 0.5mg/0.4mg Capsules