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Vandetanib
go.drugbank.com/drugs/DB05294ApprovedInvestigationalOn April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. … Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types.
Synonyms: N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-4-piperidinyl)methoxy)-4-quinazolinamine, N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amineArachidonic Acid
go.drugbank.com/drugs/DB04557ApprovedInvestigationalWithdrawnAn unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. … It is formed by the synthesis from dietary linoleic acid and is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. [PubChem]
Mixtures: SIMILAC ALIMENTUM 400 G TOZMGD-024
go.drugbank.com/drugs/DB17265InvestigationalMGD-024 is an anti-CD123/anti-CD3 bispecific DART molecule.
Tislelizumab
go.drugbank.com/drugs/DB14922ApprovedInvestigationalThis approval was based on positive results demonstrated in the RATIONALE 302 study, where an 8.6-month median overall survival rate was observed for tislelizumab treatment compared to 6.3-month for chemotherapy … [L49439] Tislelizumab was also approved by the FDA on March 14, 2024.[L50346] It has subsequently been approved for additional cancers in the US and EU. [L49349]
Norclozapine
go.drugbank.com/drugs/DB05766InvestigationalIt combines an atypical antipsychotic efficacy profile with the added potential benefit of enhanced cognition, thereby addressing one of the major challenges in treating schizophrenia today. … ACP-104, or N-desmethylclozapine, is the major metabolite of clozapine, and is being developed by ACADIA as a novel, stand-alone therapy for schizophrenia.
Synonyms: N-DesmethylclozapineRattus norvegicus skin
go.drugbank.com/drugs/DB10608ApprovedRattus norvegicus skin or pelt is used in allergenic testing.
Categories: Non-Standardized Animal Skin Allergenic ExtractSynonyms: rat skin extract, Rattus norvegicus skinGaboxadol
go.drugbank.com/drugs/DB06554InvestigationalDevelopment of Gaboxadol was stopped in March 2007 after concerns regarding safety and efficacy. It acts on the GABA system, but in a seemingly different way from benzodiazepines and other sedatives. … Gaboxadol also known as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP) is an experimental sleep aid drug developed by Lundbeck and Merck, who reported increased deep sleep without the reinforcing
Lumacaftor
go.drugbank.com/drugs/DB09280ApprovedInvestigational, and improvements in CF symptoms. … results in impaired production of the CFTR protein, thereby causing a significant reduction in the amount of ion transporter present on cell membranes.
Technetium Tc-99m sestamibi
go.drugbank.com/drugs/DB09161ApprovedInvestigationalThe drug is a coordination complex consisting of the radioisotope technetium-99m bound to six methoxyisobutylisonitrile (MIBI) ligands, hence the name sesta (6) MIBI.. … Technetium Tc-99m sestamibi (commonly sestamibi) is a pharmaceutical agent used in nuclear medicine imaging.
Categories: Compounds used in a research, industrial, or household settingDostarlimab
go.drugbank.com/drugs/DB15627ApprovedInvestigationalA prospective phase II study in patients with mismatch repair-deficient locally advanced rectal cancer resulted in all twelve patients exhibiting a complete clinical response.[A248905] … , including those of the skin, lung, kidneys, and liver.