Technetium Tc-99m sestamibi is a radiopharmaceutical diagnostic agent used in nuclear medicine imaging tests to detect coronary artery disease and evaluate myocardial function. The drug is a coordination complex consisting of the radioisotope technetium-99m bound to six methoxyisobutylisonitrile (MIBI) ligands, hence the name sesta (6) MIBI..
- Primary indication
- Technetium Tc 99m Sestamibi is indicated for: 1) detecting coronary artery disease by localizing myocardial ischemia (reversible defects) and infarction (non-reversible defects); and 2) evaluating myocardial function and developing information for use in patient management...Curator reviewed · 1 structured indication
- Formula / weight
- C36H66N6O6Tc · 775.96 g/mol (avg)
- First approval
- United States, 2009
- Also known as
- 99m Tc-sestamibi · 99m-Tc sestamibi · 99mTc sestamibi · 99mTc-sestamibi · Sestamibi
- Brand names
Resolves to
Clinical / RWD
Structure
InChIKey
ZBTQTVSNLRPJHI-UHFFFAOYSA-NSMILES[Tc+].COC(C)(C)C[N+]#[C-].COC(C)(C)C[N+]#[C-].COC(C)(C)C[N+]#[C-].COC(C)(C)C[N+]#[C-].COC(C)(C)C[N+]#[C-].COC(C)(C)C[N+]#[C-]Transporters
What you can answer from here — as of August 31, 2026
2TransportersSubstrate / inhibitor direction, not just membershipListed above
Which other approved drugs treat the same conditions as Technetium Tc-99m sestamibi, and which companies have late-stage candidates in those indications?
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